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Active and passive heat stress similarly compromises tolerance to a simulated hemorrhagic challenge (1104.22)

2014· article· en· W4205772211 on OpenAlexaff
James Pearson, Rebekah A. I. Lucas, Zachary J. Schlader, Jiexiu Zhao, Daniel Gagnon, Craig G. Crandall

Bibliographic record

VenueThe FASEB Journal · 2014
Typearticle
Languageen
FieldMedicine
TopicThermoregulation and physiological responses
Canadian institutionsCentre for Global Health Research
FundersNational Institutes of HealthU.S. Department of Defense
KeywordsHeat stressLower bodyMedicineHeart rateCore (optical fiber)Skin temperatureCore temperatureInternal medicineCardiologyAnesthesiaBlood pressureMaterials scienceAnimal scienceBiomedical engineeringBiology

Abstract

fetched live from OpenAlex

Passive heat stress increases core and skin temperatures and reduces tolerance to simulated hemorrhage, as assessed via lower body negative pressure (LBNP). It is unknown whether exercise induced heat stress reduces LBNP tolerance to a similar extent relative to passive heat stress. Eight males (32 ± 7 yrs, 176 ± 8 cm, 77.0 ± 9.8 kg) underwent LBNP to pre‐syncope on three separate and randomized occasions: passive heat stress and two occasions of exercise induced heat stress where skin temperature was moderate (~36°C, Active 36) or warm (~38°C, Active 38). LBNP tolerance was quantified using the cumulative stress index (CSI). Prior to LBNP, increases in core temperature were similar in all trials (1.18 ± 0.20°C; P < 0.05), and while mean skin temperature was similar between passive heat stress (38.2 ± 0.5°C) and Active 38 (38.2 ± 0.8°C; P = 0.90) both trials were greater compared to Active 36 (36.6 ± 0.5°C; P < 0.05). LBNP tolerance was not different between passive heat stress and Active 38 (383 ± 223 and 322 ± 178 CSI; P = 0.12) but both were similarly reduced relative to the Active 36 (516 ± 147 CSI, both P < 0.05). At pre‐syncope mean arterial pressure and heart rate were not different between trials. These data suggest that tolerance to a simulated hemorrhagic challenge is similar following passive and exercise induced heat stress when skin temperatures are similarly elevated. Grant Funding Source : DOD: W81XWH‐09‐2‐0194 and NIH: HL61388

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.011

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0030.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.023
GPT teacher head0.280
Teacher spread0.257 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2014
Admission routes1
Has abstractyes

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