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Record W4205798640 · doi:10.31219/osf.io/bn862

Soto J & al_2021_SARS-CoV-2_ECCC

2021· preprint· en· W4205798640 on OpenAlexaboutno aff
Julio C. Soto, Mireille Barakat, Juliana Ayres Hutter, Marilou Kiely, Sandrine Moreira, B. Jesse Shapiro, Carmen Lía Murall, Nicolas Parenteau, Joane Désilets, Richard Lessard

Bibliographic record

Venuenot available
Typepreprint
Languageen
FieldMedicine
TopicSARS-CoV-2 and COVID-19 Research
Canadian institutionsnot available
Fundersnot available
KeywordsAsymptomaticOutbreakTransmission (telecommunications)EpidemiologyDemographyLineage (genetic)Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)PandemicPopulationCoronavirus disease 2019 (COVID-19)MedicinePhylogenetic treeVirologyPediatricsBiologyGeneticsInternal medicineDiseaseGeneSociology

Abstract

fetched live from OpenAlex

Background: Following an outbreak in April 2020 in Quebec, Canada, an investigation was carried out to characterize SARS-CoV-2 transmission within an Emergency Childcare Centre (ECCC) setting.Methods: The study population consisted of all the children and employees who attended the ECCC as well as household contacts of the confirmed COVID-19 cases. Of the 120 individuals in the study, five cases were confirmed by epidemiological link and 25 were identified as COVID-19 by RT-PCR among which 19 were analysed by viral whole genome sequencing. Descriptive epidemiology, social network visualization, and phylogenetic analysis were used. The study period was April 9 to May 18, 2020.Findings: Phylogenetic analysis identified two separate introductions of distinct lineages of SARS-CoV-2 and estimated an average reproductive value of R = 1.9 (range 0.9 - 4.9) with a mean doubling time of 3.2 days (range 2.1 - 5.2). The first and most prevalent lineage was introduced by two asymptomatic children who were likely infected by their parent, a confirmed COVID-19 case working in a long-term care centre. Among infected household adults, attack rates were significantly higher in mothers than fathers (risk ratio = 4.5; 95% CI= 1.1-18.7). The extent of transmission makes it one of the largest documented outbreaks in a daycare in Canada.Interpretation: The analyses carried out showed the probable origin and direction of the transmission of the infection (adult-child, child-adult, and child-child), thus highlighting how asymptomatic children can efficiently transmit SARS-CoV-2.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.934
Threshold uncertainty score0.278

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0010.002
Science and technology studies0.0020.001
Scholarly communication0.0020.000
Open science0.0010.001
Research integrity0.0010.000
Insufficient payload (model declined to judge)0.0660.012

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.099
GPT teacher head0.394
Teacher spread0.295 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations1
Published2021
Admission routes1
Has abstractyes

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