Pergolide and cabergoline were associated with increased risk for newly diagnosed cardiac valve regurgitation
Bibliographic record
Abstract
EtiologyMay 1, 2007Pergolide and cabergoline were associated with increased risk for newly diagnosed cardiac valve regurgitationDavid Massel, MD, Neville Suskin, MDDavid Massel, MDLondon Health Sciences Centre, London, Ontario, Canada (D.M., N.S.)Search for more papers by this author, Neville Suskin, MDLondon Health Sciences Centre, London, Ontario, Canada (D.M., N.S.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/ACPJC-2007-146-3-075 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinkedInRedditEmail Source CitationSchade R, Andersohn F, Suissa S, Haverkamp W, Garbe E. Dopamine agonists and the risk of cardiac-valve regurgitation. N Engl J Med. 2007;356:29-38. https://pubmed.ncbi.nlm.nih.gov/17202453Clinical Impact RatingsGIM/FP/GP: Cardiology: Neurology: References1 Spatz M. Pathogenetic studies of experimentally induced heart lesions and their relation to carcinoid syndrome. Lab Invest. 1964;13:288-300. [PMID: 14127033] Google Scholar2 Connolly HM, Crary JL, McGoon MD, et al. Valvular heart disease associated with fenfluramine-phentermine. N Engl J Med. 1997;337:581-8. [PMID: 9271479] Google Scholar3 Roth BL. Drugs and valvular heart disease. N Engl J Med. 2007;356:6-9. [PMID: 17202450] Google Scholar4 Rothman RB, Baumann MH, Savage JE, et al. Evidence for possible involvement of 5-HT(2B) receptors in the cardiac valvulopathy associated with fenfluramine and other serotonergic medications. Circulation. 2000;102:2836-41. [PMID: 11104741] Google Scholar5 Clarke CE, Deane KH. Cabergoline for levodopa-induced complications in Parkinson's disease. Cochrane Database Syst Rev. 2001;(1):CD001518. [PMID: 11279720] Google Scholar Author, Article, and Disclosure InformationAffiliations: London Health Sciences Centre, London, Ontario, Canada (D.M., N.S.) PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails May 1, 2007Volume 146, Issue 3Page: 75KeywordsAdverse eventsCarcinoid tumorCardiovascular therapyDatabasesDilated cardiomyopathyDopamineDrugsEndocarditisHeart failureLevodopaMedical risk factorsMyocarditisNeurologyParkinson diseasePopulation statisticsPrimary careRestless legs syndromeSerotoninValvular diseases ePublished: 9 March 2020 Issue Published: May 1, 2007 Copyright & PermissionsCopyright © 2007 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.005 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".