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Record W4205930483 · doi:10.1016/s2468-1253(21)00223-5

Therapeutic drug monitoring of biologics in inflammatory bowel disease: unmet needs and future perspectives

2022· article· en· W4205930483 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

Venue˜The œLancet. Gastroenterology & hepatology · 2022
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicInflammatory Bowel Disease
Canadian institutionsMcGill University Health Centre
FundersSan Diego Digestive Diseases Research Center, School of Medicine, University of California, San DiegoCilagNational Institute of Diabetes and Digestive and Kidney DiseasesBristol-Myers SquibbSamsungIsrael National Road Safety AuthorityVlaamse regeringGenentechAstraZenecaAllerganMylanNational Institutes of HealthGilead SciencesLEO PharmaNovo NordiskNorgineFonds Wetenschappelijk OnderzoekMitsubishi Tanabe Pharma CorporationCelltrionVifor PharmaAmerican Gastroenterological AssociationCelgenePfizerBiogenAmgenEli Lilly and Company
KeywordsTherapeutic drug monitoringInflammatory bowel diseaseRheumatoid arthritisCertolizumab pegolPharmacogeneticsDrugDisease monitoringInflammatory Bowel DiseasesClinical trialInflammatory arthritis

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.001
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.235
Teacher spread0.226 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it