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Record W4206886443

A large-scale whole genome sequence-based analysis discovered novel genetic variants influencing bone mineral density: Results from the GEFOS and UK10K Consortia

2014· preprint· en· W4206886443 on OpenAlexaff
Hou‐Feng Zheng, Vincenzo Forgetta, Yi‐Hsiang Hsu, Karol Estrada, Paul Leo, Jonathan H. Tobias, Charles Kooperberg, Ching‐Ti Liu, Alberto Roselló‐Díez, Daniel S. Evans, Carrie M. Nielson, Urika Petterson-Kymmer, Joel Eriksson, Tony Kwan, Klaudia Walter, Yasin Memari, Shane Mc Carthy, Josine L. Min, Jie Huang, Petr Danecek, Beth Wilmot, Rui Li, Wen‐Chi Chou, Lauren E. Mokry, Alireza Moayyeri, Melina Claussnitzer, Chia‐Ho Cheng, Warren Cheung, Carolina Medina‐Gómez, Bing Ge, Shu‐Huang Chen, Kwangbom Choi, Ling Oei, James A. Fraser, Robert Kraaij, Matthew Hibbs, Celia L. Gregson, Denis Paquette, Albert Hofman, Carl Wibom, Mhairi Marshall, Brooke Gardiner, Paul L. Auer, Li Hsu, Nathalie van der Velde, Beatrice Melin, John P. Kemp, Adrian Sayers, Yanhua Zhou, Sophie Caldérari, Matthew T. Maurano, Jeroen van Rooij, Chris Carlson, Ulrike Peters, Soizik Berlivet, Josée Dostie, Claes Ohlsson, André G. Uitterlinden, David Goltzman, Tomi Pastinen, Elin Grundberg, Dominique Gaugier, Eric Orwoll, David Karasik, Chitra Lekha Dahia, Nicholas J. Timpson, Nicole Soranzo, Richard Durbin, Scott G. Wilson, Matthew A. Brown, Tim D. Spector, L. Adrienne Cupples, Celia M.T. Greenwood, Cynthia A. Loomis, Cheryl L. Ackert‐Bicknell, Alexandra L. Joyner, Rebecca D. Jackson, Emma L. Duncan, David M. Evans, Fernando Rivadeneira, Douglas P. Kiel, Brent Richards

Bibliographic record

VenueHAL (Le Centre pour la Communication Scientifique Directe) · 2014
Typepreprint
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicDigestive system and related health
Canadian institutionsGenome CanadaMcGill University
Fundersnot available
KeywordsScale (ratio)Sequence (biology)GenomeWhole genome sequencingComputational biologyBone mineralComputer scienceGeneticsBiologyGeneGeographyCartographyOsteoporosis
DOInot available

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.003
metaresearch head score (Gemma)0.001
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.875
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0030.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.001
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.013
GPT teacher head0.233
Teacher spread0.219 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designBench or experimental
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2014
Admission routes1
Has abstractno

Explore more

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