← Back to cohort
Finerenone in Patients With Chronic Kidney Disease and Type 2 Diabetes According to Baseline HbA1c and Insulin Use: An Analysis From the FIDELIO-DKD Study
Ellen Burgess, Rajiv Agarwal, Stefan D. Anker, Gerasimos Filippatos, Bertram Pitt, Luís M. Ruilope, Pieter Gillard, Richard J. MacIsaac, Julio Wainstein, Amer Joseph, Meike Brinker, Lothar Roessig, Charlie Scott, George L. Bakris, Augusto Vallejos, Guntram Schernthaner, Maria Eugênia Fernandes Canziani, Theodora Temelkova‐Kurktschiev, Ellen Burgess, Sheldon W. Tobe, Fernando González, Andrés Ángelo, Cadena Bonfanti, Carlos Jaramillo, Martin Prázný, Peter Rossing, Jorma Strand, Michel Marre, Roland E. Schmieder, Christoph Wanner, Pantelis Sarafidis, Juliana C.N. Chan, László Rosivall, Joseph A. Eustace, Ehud Grossman, Yoram Yagil, Giuseppe Remuzzi, Daisuke Koya, Takashi Wada, Magdalena Madero Rovalo, Ron T. Gansevoort, Adriaan Kooy, Trine Finnes, Froilan De Leon, Janusz Gumprecht, Fernando Teixeira e Costa, Alexander Dreval, Anantharaman Vathsala, Aslam Amod, Sin Gon Kim, Byung‐Wan Lee, Julio Pascual Santos, Bengt-Olov Tengmark, Michel Burnier, Chien‐Te Lee, Sukit Yamwong, Ramazan Sarı, Kieran McCafferty, Borys Mankovsky, Sharon G. Adler, Linda P. Fried, Robert Toto, Mark V. Williams, Tran Quang Khanh, Diego Aizenberg, Inés Bartolacci, Diego Besada, Julio Bittar, Mariano Chahin, Alicia Elbert, Elizabeth Gelersztein, Alberto Liberman, Laura Maffei, Federico Pérez Manghi, Hugo Sanabria, Gloria Viñes, Alfredo Wassermann, Walter P. Abhayaratna, Shamasunder Acharya, Elif I. Ekinci, Darren Lee, Peak Mann Mah, Craig Nelson, David Packham, Alexia Pape, Simon D. Roger, Hugo Stephenson, Michael Suranyi, Gary Wittert, Elizabeth Vale, Martin Clodi, Christoph Ebenbichler, Evelyn Fließer-Görzer, Ursula Hanusch, Michael Krebs, Karl Lhotta, Bernhard Ludvik, Gert Mayer, Peter Neudorfer, Bernhard Paulweber, Rudolf Prager, Wolfgang Preiß, Friedrich C. Prischl, G. Schernthaner, Harald Sourij, Martin Wiesholzer, Peter Doubel, W. Engelen, Jean‐Michel Hougardy, Jean-Marie Krzesinski, Bart Maes, Marijn M. Speeckaert, Koen Stas, Luc Van Gaal, Hilde Vanbelleghem, Daniela Antunes, Roberto Botelho, Cláudia Brito, Luís Henrique Santos Canani, Maria Cerqueira, Rogério de Paula, Freddy G. Eliaschewitz, Carlos Eduardo Poli‐de‐Figueiredo, Adriana Costa e Forti, Miguel Nasser Hissa, Maurilo Leite, Emerson de Lima, Irene L. Noronha, Bruno Paolino, Nathalia Paschoalin, Raphael Paschoalin, Roberto Pecoits‐Filho, Marcio Pereira, Evandro Portes, Dalton Bertolim Précoma, Rosângela Réa, Miguel C. Riella, João Eduardo Nunes Salles, Eduardo Vasconcellos, Sérgio Vencio, Emiliya Apostolova, Radostina Boshnyashka, Ghassan Farah, Dimitar Georgiev, Valentina Gushterova, Neli Klyuchkova, Mariya Lucheva, Petya Manova, Dotska Minkova, Boyan Nonchev, Mariyana Pichmanova, Zhulieta Prakova, Rangel Rangelov, Rosen Rashkov, Pavel Stanchev, Bilyana Stoyanovska-Elencheva, Zhivko Tagarev, Theodora Temelkova-Kurktschieva, S Vasileva, Mariana Yoncheva-Mihaylova, Paul E. Barré, Brian Carlson, James Conway, Serge Cournoyer, R Dumas, Sameh Fikry, Richard Goluch, Pavel Hamet, Randolph Hart, Sam Henein, Joanne Liutkus, François Madore, Valdemar Martinho, Giuseppe Mazza, Philip A. McFarlane, Dennis D. O’Keefe, Sean Peterson, Daniel M. Schwartz, Daniel Shu, Andrew Steele, Guy Tellier, Karthik Tennankore, George Tsoukas, Richard Tytus, Louise Vitou, Michael Walsh, S. John Weisnagel, Igor Wilderman, Jean‐François Yale, Jorge Cobos, Juan Godoy, Sergio Lobos, Juan Carlos Palma, Juan Carlos Prieto, Eliana Reyes, Carmen Romero, Víctor Saavedra, Mario Vega, Ruifang Bu, Cai H, Nan Chen, Qinkai Chen, Dejun Chen, Jinluo Cheng, Youping Dong, Junwu Dong, Tianjun Guan, Chuan‐Ming Hao, Wen Huang, Fangfang Jiang, Minxiang Lei, Ling Li, Zhonghe Li, Xuemei Li, Jingmei Li, Yan Li, Xinling Liang, Bo Liang, Fang Liu, Yinghong Liu, Yuan-Tao Liu, Zhihong Liu, Gang Long, Guoyuan Lu, Weiping Lu, Yibing Lu, Ping Luo, Jianhua Ma, Zhaohui Mo, Jianying Niu, Ai Peng, Jiansong Shen, Feixia Shen, Bingyin Shi, Qing Su, Zhuxing Sun, Shuifu Tang, Nanwei Tong, Hao Wang, Xinjun Wang, Lihua Wang, Guixia Wang, Jianqin Wang, Yangang Wang, Li Wang, Jiali Wei, Tianfeng Wu, Chao-Qing Wu, Xing Changying, Fei Xiong, Xudong Xu, Ning Xu, Tiekun Yan, Aiping Yin, Longyi Zeng, Hao Zhang, Yanlin Zhang, Ying Zhang, Wenjing Zhao, Zhiquan Zhao, Hongguang Zheng, Ling Zhong, Dalong Zhu, Yongze Zhuang, Clara Arango, Sandra Barrera, Nelly Beltrán López, Diego Benitez, Guillermo Blanco, Andrés Cadena, Julián Coronel, Carlos Curé, Carlos Durán, Alexander Ariel Padrón González, Gustavo Guzmán, Eric Hernández, Jaime Ibarra, Nicolás Jaramillo, William Kattah, Dora I. Molina, Gregorio Sánchez, Mónica Terront, Freddy Trujillo, Ruben Vargas, Iván Villegas, Hernán Yupanqui, D Alferi, Michal Brada, Jiri Brezina, Petr Bucek, Tomáš Edelsberger, Drahomira Gulakova, J Zapletalová, Olga Hola, Lucie Hornova, Jana Houdova, Helena Hrmova, David Karásek, Sarka Kopecka, Richard Kovar, Eva Krčová, Jiří Kuchař, Vlasta Kutejova, H Lubanda, Ivo Matyasek, Magdaléna Mokrejšová, Libor Okenka, Jiri Pumprla, Pavel Tománek, Jesper Nørgaard Bech, Jens Faber, Gunnar Gislason, Jørgen Hangaard, Grzegorz Jaroslaw Pacyk, Claus Bogh Juhl, Thure Krarup, Morten Lindhardt, Sten Madsbad, Joan Nielsen, Ulrik Pedersen‐Bjergaard, P. L. Poulsen, Ole Rasmussen, Karoline Schousboe, Mikko Honkasalo, Kari Humaloja, Kristiina Kananen, Ilkka Kantola, Arvo Koistinen, Pirkko Korsoff, Jorma Lahtela, Sakari Nieminen, Tuomo Nieminen, Karita Sadeharju, Sakari Sulosaari, Bertrand Cariou, François Chantrel, Sylvaine Clavel, Christian Combe, Jean‐Pierre Fauvel, Karim Gallouj, D. Gouet, Bruno Guerci, Dominique Guerrot, Maryvonne Hourmant, Alexandre Klein, Christophe Mariat, Rafik Mesbah, Yannick Le Meur, Arnaud Monier, Olivier Moranne, Pierre Sérusclat, Benoı̂t Vendrely, Bruno Vergès, Philippe Zaoui, Christoph Axthelm, Andreas Bergmann, Andreas L. Birkenfeld, Hermann Braun, Klaus Busch, Christel Contzen, Stefan Degenhardt, Karl Derwahl, Thomas Giebel, Andreas Hagenow, Hermann Haller, Christoph Hasslacher, Thomas Horacek, Wolfgang Jungmair, C Kloos, Thorsten Koch, Thilo Krüger, Anja Mühlfeld, Joachim Müller, Andreas Pfützner, Frank Pistrosch, Ludger Rose, Lars Christian Rump, Volker Schettler, Ingolf Schiefke, Heike Schlichthaar, Bernd Schröppel, Thomas Schürholz, Helena Sigal, Lutz Stemler, Georg Strack, Heidrun Täschner, Nicole Toursarkissian, Diethelm Tschöpe, Achim Ulmer, Markus van der Giet, Bernhard R. Winkelmann, Ioannis Boletis, Erifili Hatziagelaki, Ioannis Ioannidis, Theodora Kounadi, Ioanna Makriniotou, Dorothea Papadopoulou, Αikaterini Papagianni, Ploumis Passadakis, Ioannis Stefanidis, Tai Pang Ip, Paul Lee, On Yan Andrea Luk, Angela Yee‐Moon Wang, Ming Wai Yeung, Dóra Bajcsi, P. Dános, Eleonóra Harcsa, Szilvia Kazup, Katalin Keltai, Róbert Kirschner, Julianna Kiss, László Kovács, Beata Lamboy, Botond Literáti-Nagy, Margit Miléder, László Nagy, Ebrahim Noori, Gábor Nyirati, Gizella Petró, Karoly Schneider, Albert Szöcs, Szilárd Vasas, Krisztina Wudi, Z Zilahi, Marianna Zsom, Joe Eustace, John Holian, Donal Reddan, Yvonne O’Meara, Rosane Abramof Ness, Faiad Adawi, Zaher Armaly, Shaul Atar, Sydney Ben Chetrit, Noa Berar Yanay, Gil Chernin, Mahmud Darawsha, Shai Efrati, Mazen Elias, Evgeny Farber, Mariela Glandt, Majdi Halabi, Khaled Khazim, Idit F. Liberty, Ofri Mosenzon, Nimer Assy, Doron Schwartz, Robert Zukermann, Aneliya Parvanova, Angelo Avogaro, Giovanni Giorgio Battaglia, Maurizio Bevilacqua, Enzo Bonora, Carlo Antonio Bossi, Paolo Calabrò, Franco Cavalot, R Cimino, Mario Cozzolino, S. David, Michele Emdin, Enrico Fiaccadori, Paolo Fiorina, Carlo Giorda, Maria Cristina Gregorini, Gaetano La Manna, Davide Maggi, Roberta Manti, Giancarla Meregalli, Antonello Pani, Norberto Perico, PierMarco Piatti, A Pisani, Antonio E. Pontiroli, Paola Ponzani, Gennaro Santorelli, Domenico Santoro, Renzo Scanziani, Ugo Teatini, Giancarlo Tonolo, Roberto Trevisan, Anna Maria Veronelli, Giorgio Luciano Viviani, Hideo Araki, Osamu Ebisui, Naruhiro Fujita, Ryuichi Furuya, Yoshiyuki Hamamoto, Masahiro Hatazaki, Terumasa Hayashi, Takayuki Higashi, Yoshihide Hirohata, Shuji Horinouchi, Masayuki Inagaki, Masao Ishii, Tamayo Ishiko, Hideaki Jinnouchi, Hidetoshi Kanai, Daisuke Kanda, Hideo Kanehara, Masayuki Kashima, Kiyoe Kato, Takeshi Katsuki, Katsunori Kawamitsu, Satsuki Kawasaki, Fumi Kikuchi, H Kikuchi, Kunihisa Kobayashi, Junko Koide, Miyuki Kubota, Yoshiro Kusano, Hajime Maeda, Sunao Matsubayashi, Kazunari Matsumoto, Yasuto Matsuo, Naoki Matsuoka, Hiroaki Miyaoka, Satoshi Murao, Mikihiro Nakayama, Jun Nakazawa, Takashi Nomiyama, Masayuki Noritake, Takayuki Ogiwara, Hiroshi Ohashi, Hideki Okamoto, Takeshi Osonoi, Nobuhiro Sasaki, Taiji Sekigami, Taro Shibasaki, Hirotaka Shibata, Junji Shinoda, Hiroshi Sobajima, Kazuya Sugitatsu, Toshiyuki Sugiura, Toru Sugiyama, Daisuke Suzuki, Hiroyuki Suzuki, Masaaki Suzuki, Asami Takeda, Asami Tanaka, Seiichi Tanaka, Izumi Tsunematsu, Makoto Ujihara, Daishiro Yamada, Masayo Yamada, Kazuo Yamagata, Ken Yamakawa, Fumiko Yamakawa, Yoshimitsu Yamasaki, Yuko Yambe, Taihei Yanagida, Hidekatsu Yanai, Tetsuyuki Yasuda, Dovilė Kriaučiūnienė, Jūratė Lašienė, Antanas Navickas, Lina Radzevičienė, Eglė Urbanavičienė, Gediminas Urbonas, Audrone Velaviciene, Rohana Abd Ghani, Nor Azizah Aziz, Li Yuan Lee, Chek Loong Loh, Norhaliza Mohd Ali, Nurain Mohd Noor, Nik Nur Fatnoon, Nik Nur Fatnoon Nik Ahmad, Jeyakantha Ratnasingam, Wan Bin, Wan Hasan, Wan Mohd Izani, Wan Mohamed, Sandro Avila Pardo, Miriam Bastidas Adrian, Alfredo Chew Wong, Guillermo Fanghänel Salmón, Guillermo González-Gálvez, Ramiro Gutiérrez Ochoa, Saúl Irizar Santana, Gustavo Méndez Machado, Luis Nevárez Ruiz, Denisse Ramos Ibarra, Gabriel Ramos López, Leobardo Sauque Reyna, Gustavo Solache Ortiz, Juan Villagordoa Mesa, René C. Bakker, J.N.M. Barendregt, Arnold H. Boonstra, Willem Jan W. Bos, Catherine B. Brouwer, Marjolijn van Buren, Mariëlle Krekels, Ruud J.M. van Leendert, Louis A.G. Lieverse, P. T. Luik, E. Lars Penne, Peter Smak Gregoor, Liffert Vogt, John Baker, Veronica Crawford, Rick Cutfield, Peter J. Dunn, Jeremy Krebs, Kingsley Nirmalaraj, Russell Scott, Nine Smuts, Erik Fink Eriksen, Hans Olav Høivik, Thomas Karlsson, Peter Scott Munk, Maria Radtke, Knut Risberg, Jan Rocke, Leidulv Solnør, Aud‐Eldrid Stenehjem, Anne-Beathe Tafjord, Glenda Pamugas, Araceli Panelo, Ronald Perez, Maribel Tanque, Louie Tirador, Michael Villa, Patrycja Butrymowicz, Kazimierz Ciechanowski, Grażyna Cieślik, Edward Franek, Michal Hoffmann, Jolanta Krzykowska, Ilona Kurnatowska, Katarzyna Landa, Adam Madrzejewski, Katarzyna Madziarska, Stanisław Mazur, Piotr Napora, Michał Nowicki, Anna Ocicka-Kozakiewicz, Barbara Rewerska, Teresa Rusicka, Jan Ruxer, Ewa Skokowska, Andrzej Stankiewicz, Tomasz Stompór, Agnieszka Tiuryn-Petrulewicz, Katarzyna Wasilewska, Bogna Wierusz‐Wysocka, Renata Wnętrzak-Michalska, Edgar Almeida, Rosa Ballesteros, Carlos Barreto, Idalina Beirão, Rita Birne, César Esteves, José Guia, Susana Heitor, Olinda Marques, Pedro Melo, Fernando Nolasco, Amalia Pereira, Cristina Roque, Francisco Rosário, Gil Silva, Ana Silva, Ana Vila Lobos, Gregorio Cortes-Maisonet, Amaury Roman-Miranda, Adrian Albota, Cornelia Bala, Hortensia Barbonta, Elena Caceaune, Doina Catrinoui, Ciprian Constantin, Adriana Dumitrescu, Nicoleta Mîndrescu, Cristina Mistode, Gabriela Negrişanu, Adriana Onaca, Silvia Paveliu, Ella Pintilei, Lavinia Pop, Amorin Remus Popa, A. Popescu, Gabriela Radulian, Iosif Szilagyi, Liana Turcu, Georgeta Văcaru, Adrian Vlad, М. Б. Анциферов, М. В. Архипов, Andrey Babkin, О. Л. Барбараш, Vitaliy Baranov, Е. А. Chernyavskaya, Arkadiy Demko, Anton Edin, Polina Ermakova, В. В. Фадеев, А. S. Galyavich, Leyla Gaysina, И. Г. Гордеев, Irina Ipatko, Marina Kalashnikova, Yuriy Khalimov, Vadim V. Klimontov, Zhanna Kobalava, Е. Д. Космачева, Н. А. Козиолова, Lyudmila Kvitkova Sergey Levashov, Р. А. Либис, Vyacheslav Marasaev, Natalia Malykh, V. V. Martynenko, Sofya Malyutina, И.А. Мерай, А. M. Mkrtumyan, Г. И. Нечаева, Н. А. Петунина, Shamil Palyutin, Л. Т. Пименов, Elena Rechkova, Tatyana Rodionova, О. Д. Рымар, Ruslan Sardinov, Olga Semenova, Alexander Sherenkov, Oleg Solovev, Е. А. Smolyarchuk, Л. Г. Стронгин, Olga P. Ukhanova, Н. В. Верлан, Natalya Vorokhobina, D. A. Yakhontov, S. S. Yаkushin, Elena Zakharova, Alsu Gafurovna Zalevskaya, О. В. Занозина, Elena Zhdanova, Larisa Zhukova, Tatyana A. Zykova, Chee Fang Sum, Sufi Muhummad Suhail, Ru‐San Tan, Edmund Wong, Jana Babikova, Ingrid Bugáňová, Andrej Džupina, Zuzana Ochodnicka, Dalibor Sosovec, Denisa Spodniakova, Fayzal Ahmed, Sindeep Bhana, Larry A. Distiller, Dirkie Jansen van Rensburg, Mukesh C. Joshi, Shaifali Joshi, Deepak Lakha, Essack Mitha, Gracjan Podgorski, Naresh Ranjith, Brian Rayner, Paul Rheeder, Mohamed Sarvan, Mary Seeber, Heidi Siebert, Mohammed Siddique Tayob, Julien Trokis, Dorothea Urbach, Louis van Zyl, Bum-Soon Choi, Moon Gi Choi, Choon Hee Chung, You‐Cheol Hwang, Chong Hwa Kim, Jae-Hyeon Kim, SinGon Kim, SungGyun Kim, Tae Hee Kim, WooJe Lee, Kang Wook Lee, Kook‐Hwan Oh, Ji Eun Oh, Yun Kyu Oh, Dong‐Jin Oh, Junbeom Park, Seok Joon Shin, Jae Myung Yu, Irene Agraz, Francisco Javier Ampudia, Hanane Bouarich, Francesca Calero, Cristina Castro, Secundino Cigarrán, Josep Cruzado Garrit, Fernando de Álvaro, Josep Galcerán, Olga González Albarrán, Julio Hernández Jaras, Meritxell Ibernón, Francisco Martínez Debén, Ma Dolores Martínez Esteban, José María Pascual Izuel, Judith Martins, Juan Diego Mediavilla, Esteban Poch, Manuel Polaina Rusillo, Carlos Sánchez Juan, José Julián, Segura de la Morena, Alfonso Soto, Maribel Troya, Annette Bruchfeld, Dan Curiac, Ken Eliasson, Malin Frank, Gregor Guron, Olof Hellberg, Margareta Hellgren, Hans Larnefeldt, Carl-Johan Lindholm, Magnus Löndahl, Erik Rein‐Hedin, Inga Soveri, Jonas Spaak, Daniel Ackermann, Stefan Bilz, Christian Förster, Stefan Kalbermatter, Andreas D. Kistler, Antoinette Péchère-Bertschi, Bernd Schultes, Chiz‐Tzung Chang, Cheng-Chieh Hung, Ju‐Ying Jiang, Shuei‐Liong Lin, Der‐Cherng Tarng, Shih‐Te Tu, Kwan‐Dun Wu, Ming‐Ju Wu, Chaicharn Deerochanawong, Chagriya Kitiyakara, Vuddhidej Ophascharoensuk, Chatlert Pongchaiyakul, Bancha Satirapoj, Necmi Eren, İbrahim Gül, Okan Gülel, İsmail Koçyiğit, Abdülbaki Kumbasar, İdris Şahın, Burak Sayın, Talat Tavlı, Sedat Üstündağ, Yavuz Yeniçerioğlu, Iryna Bondarets, Volodymyr Botsyurko, Viktoriia Chernikova, Oleksandra Donets, I. M. Fushtey, Mariia Grachova, Anna Isayeva, Dmytro Kogut, Julia Komisarenko, Н. А. Кравчун, Kateryna Malyar, Liliya Martynyuk, Vitaliy Maslyanko, Halyna Myshanych, Larysa Pererva, Н. О. Перцева, Oleksandr Serhiyenko, Ivan Smirnov, Л.К. Соколова, Vasyl Stryzhak, Maryna Vlasenko, Ahmad Abou-Saleh, Jonathan Barratt, Cuong Dang, Hassan Kahal, Adam Kirk, Anne Kilvert, Sui Phi Kon, Dipesh Patel, Sam Rice, Vijayaraman Arutchelvam, Yuk-ki Wong, Martin Gibson, Mona Wahba, Reza Zaidi, Idalia Acosta, Atoya Adams, Dilawar Ajani, Slamat Ali, Radica Z. Alicic, Amer Al‐Karadsheh, Sreedhara Alla, Nabil Andrawis, Ahmed Arif, Ahmed K. Awad, Masoud Azizad, Michael Bahrami, Shweta Bansal, Steven Barag, Ahmad Barakzoy, Mark Barney, Joshua I. Barzilay, Khalid Bashir, Jose Bautista, Srinivasan Beddhu, Diogo Belo, Sabrina Benjamin, Ramin Berenji, Anuj Bhargava, Jose Birriel, Stephen Brietzke, Frank C. Brosius, Osvaldo Brusco, Anna Burgner, Robert S. Busch, Rafael Canadas, Maria Luiza Caramori, José Cardona, Christopher Case, Humberto Cruz, Ramprasad Dandillaya, Dalia Dawoud, Zia Ud Din, Bradley P. Dixon, Ankur Doshi, James Drakakis, Mahfouz El Shahawy, Ashraf El‐Meanawy, Mohammed El-Shahawy, John Evans, George Z. Fadda, Umar Farooq, Roland Fernando, Raymond Fink, Brian First, David Fitzpatrick, John M. Flack, Patrick Fluck, Leon Fogelfeld, Vivian Fonseca, Juan P. Frías, Claude Galphin, Luis Garcia-Mayol, Gary W. Goldstein, Edgar R. Gonzalez, Francisco Gonzalez-Abreu, Ashwini Gore, David Grant, Violet Habwe, Maxine Hamilton, Jamal Hammoud, Stuart Handelsman, Israel Hartman, Glenn Heigerick, Andrew Henry, Germán T. Hernández, Carlos Hernández-Cassis, Carlos Herrera, Joachim Hertel, Wenyu Huang, Rogelio Iglesias, Ali Iranmanesh, Timothy Jackson, Mahendra Jain, Kenneth Jamerson, Karen S. Johnson, Eric Judd, Joshua S. Kaplan, Zeid Kayali, Bobby V. Khan, Mohammad Iqbal Khan, Sourabh Kharait, M. Sue Kirkman, Nelson Kopyt, Wayne Kotzker, Csaba P. Kövesdy, Camil Kreit, Arvind Krishna, Saeed Kronfli, Keung Lee, Derek LeJeune, Brenda Lemus, Carlos Leon-Forero, Douglas Linfert, Henry Lora, Alexander Lurie, Geetha Maddukuri, Alexander R. Magno, Louis Maletz, Sreedhar Mandayam, Mariana Markell, Ronald K. Mayfield, Caroline Mbogua, Dierdre McMullen, Carl Meisner, Stephen D. Minton, Bharat Mocherla, Rajesh Mohandas, Manuel Montero, Moustafa Sherief Moustafa, Salil Nadkarni, Samer Nakhle, Jesús Navarro, Nilda Neyra, Romanita Nica, Philip Nicol, Paul Norwood, Visal Numrungroad, Richard O’Donovan, A. Ola Odugbesan, Jorge Paoli-Bruno, Samir V. Parikh, Rakesh Patel, Aldo J. Peixoto, Pablo E. Pérgola, Alan Perlman, Karlton Pettis, Roberto Pisoni, Mirela Ponduchi, Jorge Posada, Sharma Prabhakar, Jai Radhakrishnan, Mahboob U. Rahman, Rupesh Raina, Anjay Rastogi, Efrain Reisin, Marc Rendell, David Robertson, Michael V. Rocco, Hugo Romeu, Sylvia E. Rosas, Jack Rosenfeld, Dennis L. Ross, Jeffrey Rothman, Lance Rudolph, Yusuf Ruhullah, Gary Ruoff, Jeffrey Ryu, Mandeep Sahani, Ramin Sam, Garfield Samuels, William Sanchez, Vladimir Santos, Scott G. Satko, Sanjeev Saxena, David A. Scott, Gilberto Seco, Melvin Seek, Harvey Serota, Tariq Shafi, Nauman Shahid, Michael H. Shanik, Santosh Sharma, Arjun Sinha, James Smelser, Mark Smith, Kyaw Soe, Richard Solomon, Eugene Soroka, Joseph Soufer, Bruce Spinowitz, Leslie Spry, Rosa Suarez, Bala Subramanian, Harold M. Szerlip, Aparna Tamirisa, Stephen Thomson, Tuan-Huy Tran, Richard Treger, Gretel Trullenque, Thomas Türk, Guillermo E. Umpierrez, Daniel Urbach, Martin Valdes, Shujauddin Valika, Damaris Vega, Peter N. Weissman, Adam Whaley‐Connell, Jonathan Winston, Jonathan Wise, Alan Wynne, Steven Zeig, Phuong Chu, Lam Van Hoang, Nguyen Thi Phi Nga, Pham Nguyen Son, Lan Phuong Tran
Bibliographic record
VenueDiabetes Care · 2022
Typearticle
Languageen
FieldMedicine
TopicHormonal Regulation and Hypertension
Canadian institutionsUniversity of Calgary
FundersAbbott VascularNational Institutes of HealthServierVifor PharmaRelypsaAstellas PharmaNovo NordiskImpulse DynamicsJanssen PharmaceuticalsGilead SciencesAkebia TherapeuticsSteno Diabetes Center CopenhagenBayer HealthCareEuropean CommissionSanofiBayerOtsuka AmericaFresenius Medical Care North AmericaEli Lilly and CompanyAstraZenecaIronwood Pharmaceuticals, IncorporatedAmgen
KeywordsMedicineDiabetes mellitusType 2 diabetesKidney diseaseInternal medicineInsulinDiseaseBaseline (sea)Endocrinology
Abstract
OBJECTIVE: Finerenone significantly improved cardiorenal outcomes in patients with chronic kidney disease (CKD) and type 2 diabetes (T2D) in the Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease trial. We explored whether baseline HbA1c level and insulin treatment influenced outcomes. RESEARCH DESIGN AND METHODS: Patients with T2D, urine albumin-to-creatinine ratio (UACR) of 30-5,000 mg/g, estimated glomerular filtration rate (eGFR) of 25 to <75 mL/min/1.73 m2, and treated with optimized renin-angiotensin system blockade were randomly assigned to receive finerenone or placebo. Efficacy outcomes included kidney (kidney failure, sustained decrease ≥40% in eGFR from baseline, or renal death) and cardiovascular (cardiovascular death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure) composite endpoints. Patients were analyzed by baseline insulin use and by baseline HbA1c <7.5% (58 mmol/mol) or ≥7.5%. RESULTS: Of 5,674 patients, 3,637 (64.1%) received insulin at baseline. Overall, 5,663 patients were included in the analysis for HbA1c; 2,794 (49.3%) had baseline HbA1c <7.5% (58 mmol/mol). Finerenone significantly reduced risk of the kidney composite outcome independent of baseline HbA1c level and insulin use (Pinteraction = 0.41 and 0.56, respectively). Cardiovascular composite outcome incidence was reduced with finerenone irrespective of baseline HbA1c level and insulin use (Pinteraction = 0.70 and 0.33, respectively). Although baseline HbA1c level did not affect kidney event risk, cardiovascular risk increased with higher HbA1c level. UACR reduction was consistent across subgroups. Adverse events were similar between groups regardless of baseline HbA1c level and insulin use; few finerenone-treated patients discontinued treatment because of hyperkalemia. CONCLUSIONS: Finerenone reduces kidney and cardiovascular outcome risk in patients with CKD and T2D, and risks appear consistent irrespective of HbA1c levels or insulin use.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.010
Threshold uncertainty score0.399
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.012
GPT teacher head0.239
Teacher spread0.227 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations35
Published2022
Admission routes1
Has abstractyes