An overview of human infections caused by <em>Staphylococcus pseudintermedius:</em> A zoonotic risk of the oldest friend
Bibliographic record
Abstract
Staphylococcus pseudintermedius is colonized in 90% of healthy dogs and the infection has also been reported in humans who have close contact with dogs. S. pseudintermedius is a Gram positive coagulase positive coccus which is an opportunistic pathogen. Human infection has been reported less frequently either due to misidentification or misdiagnosis or to underreporting. The objective of this overview is to highlight the epidemiology, clinical presentation, importance of laboratory tests and antimicrobial resistance of S. pseudintermedius in humans.Human infections of S. pseudintermedius have been reported as case studies or clusters of infections in the literature. Several cases have been reported among the adult population, and in patients with metabolic diseases such as diabetes mellitus, immunocompromised states such as AIDS, cancers, and autoimmune diseases. The organism had been isolated and identified both in healthy people and individuals with adverse clinical outcomes. S. pseudintermedius causes skin and soft tissue infections, catheter associated infections and surgical site infections in humans. The incidence of skin and soft tissue infection by S. pseudintermedius in humans was 0.025% in Canada. Methicillin resistance S. pseudintermedius (MRSP) has been isolated both in healthy people and associated with clinical infections. MRSP is often multidrug resistant and therapeutic options are limited. Multidrug resistance has been detected in methicillin susceptible S. pseudintermedius (MSSP). Close association of a canine host is the major risk factor in humans and vulnerable individuals need to be persuaded to practice hygienic practices to minimize the risk of zoonotic infection.In conclusion, differentiation of S. pseudintermedius from S. aureus is required to understand the epidemiology of the disease, diagnosis, clinical presentation, and further interpretation of antimicrobial resistance in the human clinical context. Suitable hygienic practices post handling of dogs and improvement of laboratory facilities would help minimize the incidence of S. pseudintermedius infections in humans.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.004 | 0.003 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.001 | 0.001 |
| Insufficient payload (model declined to judge) | 0.004 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".