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Record W4210449061 · doi:10.1002/alz.049472

Effect of aging and neurodegeneration on contextual processing

2021· article· en· W4210449061 on OpenAlexaff
Kim Tran, Andrew McDonald, Ryan C.N. D’Arcy, Xiaowei Song

Bibliographic record

VenueAlzheimer s & Dementia · 2021
Typearticle
Languageen
FieldNeuroscience
TopicNeural and Behavioral Psychology Studies
Canadian institutionsUniversity of British ColumbiaFraser HealthSimon Fraser University
Fundersnot available
KeywordsNeurodegenerationContext (archaeology)PsycINFODementiaCognitionPsychologyCognitive agingInformation processingNeuroscienceCognitive psychologyHealthy agingCognitive declineDiseaseMedicineGerontologyMEDLINEPathology

Abstract

fetched live from OpenAlex

Background Contextual processing (or context processing; CP) is an integral component of cognition. Contextual processing allows people to manage their thoughts and actions by adjusting to surroundings. The process involves the formation of internal representations of context in relation to the environment, maintenance of information over a period of time, and the updating of mental representations to reflect environmental changes. Each of these functions can be affected by aging and associated brain conditions. Here, we update the current research investigating the impact of aging and neurodegeneration on CP. Method Through searching the PubMed, PsycINFO, and Google Scholar databases, 18 studies that focused on aging, mild cognitive impairment (MCI), Alzheimer’s disease (AD), and Parkinson's disease (PD) impacts on CP were retrieved and reviewed in detail. Result Older adults of normal aging had a delayed onset and reduced amplitude of electrophysiological response to information detection, comparison, and execution. MCI patients demonstrated clear signs of impaired CP compared to normal aging. The only study reporting CP in AD suggested a decreased proactive control in maintaining contextual information, but seemingly intact reactive control. On the other hand, PD without dementia showed limited ability to use contextual information in cognitive and motor processes, exhibiting impaired reactive control. Conclusion Data suggest that accelerated aging and neurodegeneration can further impact the changes in CP with age, providing insights for improving intervention strategies. This study highlights the need for increased attention to research this important but understudied field.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.005
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.003
Threshold uncertainty score0.007

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.005
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.002
Science and technology studies0.0000.001
Scholarly communication0.0010.001
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0020.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.089
GPT teacher head0.362
Teacher spread0.273 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes1
Has abstractyes

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