Deletion of protein tyrosine phosphatase 1B (PTP1B) prevents type 1 diabetes‐induced vascular dysfunction
Bibliographic record
Abstract
Impaired vascular function is a common feature in type I diabetic patients. PTP1B deletion prevents endothelial dysfunction and leptin infusion restores cardiovascular dysfunction induced by type I diabetes. We hypothesized that increasing leptin sensitivity via PTP1B deletion prevents vascular dysfunction in type I diabetic mice. Type I diabetes was induced with streptozotocin (STZ) in male and female Balb/C and PTP1B KO mice. Vascular function was studied after 24 days of STZ on aortic rings mounted on a wire myograph. Glycemia was significantly increased with STZ and further exaggerated by PTP1B deletion in male mice only (Balb/CMSTZ: 342±18 vs PTP1BMSTZ: 509±26 mg/dl, p<0.05). Endothelial function assessed via acetylcholine (ACh)‐mediated relaxation was reduced in both male and female Balb/C mice but preserved in PTP1B KO animals. While LNAME completely abolished ACh‐mediated relaxation in Balb/C mice, addition of indomethacin was required to abolish relaxation in PTP1B KO mice treated with STZ, suggesting dilatory cyclooxygenase derivatives involvement. Phenylephrine (PE)‐induced constriction was increased by STZ in male and female Balb/C, but preserved in PTP1B KO male mice only. Taken together these data indicate that PTP1B deletion protects against the harmful vascular effects of type I diabetes, independent of hyperglycemia and with more pronounced effects in male than female mice.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.002 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".