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Record W4210802538 · doi:10.1515/ci-2021-0425

One Hundred Years of Insulin

2021· article· en· W4210802538 on OpenAlexaboutno aff

Bibliographic record

VenueChemistry International · 2021
Typearticle
Languageen
FieldMedicine
TopicDiabetes, Cardiovascular Risks, and Lipoproteins
Canadian institutionsnot available
Fundersnot available
KeywordsBiochemistClassicsTrustworthinessMedicineGerontologyPsychologyHistory

Abstract

fetched live from OpenAlex

Abstract The 1923 Nobel Prize in Physiology or Medicine was awarded jointly to Canadian physician Frederick Grant Banting (1891-1941) and Scottish biochemist and physiologist John James Macleod (1876-1935) “for the discovery of insulin”. It was a remarkable finding since diabetes mellitus was an untreatable and often lethal disease until then. Much has been written about Banting and Macleod’s breakthrough research conducted at the University of Toronto starting in November 1920, including the key roles played by their trustworthy assistants, medical student Charles Best and biochemist James Collip. On the other hand, much less has been written about the pioneering research of Romanian physiologist Nicolae Paulescu (1869-1931), whose work on the metabolic effects of canine pancreatic extracts predates that of Banting and Macleod but was interrupted by World War I. Should Best, Collip, or Paulescu have also shared the Nobel Prize?

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.003
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.022
Threshold uncertainty score0.073

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.003
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.001
Science and technology studies0.0010.002
Scholarly communication0.0030.002
Open science0.0010.002
Research integrity0.0010.005
Insufficient payload (model declined to judge)0.0220.012

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.014
GPT teacher head0.246
Teacher spread0.233 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes1
Has abstractyes

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