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Record W4210914372 · doi:10.1093/genetics/iyac003

WormBase in 2022—data, processes, and tools for analyzing <i>Caenorhabditis elegans</i>

2022· article· en· W4210914372 on OpenAlexaff
Paul A. Davis, Magdalena Zarowiecki, Valerio Arnaboldi, Andrés Becerra, Scott Cain, Juancarlos Chan, Wen J. Chen, Jaehyoung Cho, Eduardo da Veiga Beltrame, Stavros Diamantakis, Sibyl Gao, Dionysios Grigoriadis, Christian A Grove, Todd Harris, Ranjana Kishore, Tuan Anh Le, Raymond Lee, Manuel Luypaert, Hans‐Michael Müller, Cecilia Nakamura, Paulo Nuin, Michael Paulini, Mark Quinton-Tulloch, Daniela Raciti, Faye H. Rodgers, Matthew Russell, Gary Schindelman, Archana Singh, Tim Stickland, Kimberly Van Auken, Qinghua Wang, Gary W. Williams, A. Jordan Wright, Karen Yook, Matthew Berriman, Kevin Howe, Tim Schedl, Lincoln Stein, Paul W. Sternberg

Bibliographic record

VenueGenetics · 2022
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicGenetics, Aging, and Longevity in Model Organisms
Canadian institutionsOntario Institute for Cancer Research
FundersU.S. National Library of MedicineNational Human Genome Research InstituteMedical Research Council
KeywordsCaenorhabditis elegansBiologyWorkflowGenomicsData scienceData curationGenomeAllianceCaenorhabditisComputational biologyGeneticsComputer scienceDatabaseGene

Abstract

fetched live from OpenAlex

WormBase (www.wormbase.org) is the central repository for the genetics and genomics of the nematode Caenorhabditis elegans. We provide the research community with data and tools to facilitate the use of C. elegans and related nematodes as model organisms for studying human health, development, and many aspects of fundamental biology. Throughout our 22-year history, we have continued to evolve to reflect progress and innovation in the science and technologies involved in the study of C. elegans. We strive to incorporate new data types and richer data sets, and to provide integrated displays and services that avail the knowledge generated by the published nematode genetics literature. Here, we provide a broad overview of the current state of WormBase in terms of data type, curation workflows, analysis, and tools, including exciting new advances for analysis of single-cell data, text mining and visualization, and the new community collaboration forum. Concurrently, we continue the integration and harmonization of infrastructure, processes, and tools with the Alliance of Genome Resources, of which WormBase is a founding member.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.008
metaresearch head score (Gemma)0.021
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Software · Consensus signal: none
Teacher disagreement score0.036
Threshold uncertainty score0.120

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0080.021
Meta-epidemiology (narrow)0.0030.002
Meta-epidemiology (broad)0.0040.002
Bibliometrics0.0110.011
Science and technology studies0.0020.001
Scholarly communication0.0080.007
Open science0.0060.008
Research integrity0.0030.004
Insufficient payload (model declined to judge)0.0360.050

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.022
GPT teacher head0.253
Teacher spread0.232 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreSoftware

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations311
Published2022
Admission routes1
Has abstractyes

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