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Record W4211238223 · doi:10.1080/10937400490258873

AVIAN IMMUNOTOXICOLOGY

2004· review· en· W4211238223 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.

Bibliographic record

VenueJournal of Toxicology and Environmental Health Part B · 2004
Typereview
Languageen
FieldMedicine
TopicZoonotic diseases and public health
Canadian institutionsUniversity of Saskatchewan
Fundersnot available
KeywordsImmunotoxicologyImmune systemBiologyImmunocompetenceImmunosuppressionZoologyEcologyExposomeImmunologyGenetics

Abstract

fetched live from OpenAlex

Methods for studying the avian immune system have matured during the past two decades, with laboratory studies predominating in earlier years and field studies being conducted only in the past decade. One application has been to determine the potential for environmental contaminants to produce immune suppression, while another research direction is looking at the evolutionary significance of a robust immune system, and the relationship between immune competence and fitness parameters. Laboratory studies of immunosuppression following exposure of birds to environmental contaminants have adapted conventional mammalian methods to the avian immune system, and both lines of research have developed field-deployable measures of immune function. This review describes the avian immune system with emphasis on how it differs from the better known mammalian system, reviews the literature on contaminant-induced immunosuppression, and discusses the work on evolutionary biology of avian immunocompetence. Evidence indicates that the field of avian immunology is technically robust, even for nontraditional species such as passerines, seabirds, raptors, and other free-ranging species. It is now possible to screen chemicals for immunotoxicological properties following the same tiered approach that has been established for mammals. Despite the increased capacity and interest in avian field studies, there has not yet been a reported study of measured immune suppression associated with an avian epizootic. It is more likely that the immune suppression in adult birds resulting from low-level chronic stress (e.g., crowding onto poor quality habitat, food reductions, or climate stress) and (or) environmental contaminants causes slow but consistent morbidity and mortality associated with multiple pathogens, rather than an acute epizootic with a single pathogen. Increased fitness costs associated with such stress may significantly alter genetic diversity and species survival over time.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesMeta-epidemiology (narrow), Insufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Other design · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.981
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0030.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0010.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.044
GPT teacher head0.371
Teacher spread0.326 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it