A72 GASTROPARESIS: CLINICAL CHARACTERISTICS, ETIOLOGIES & RESPONSE TO TREATMENT
Bibliographic record
Abstract
Abstract Background Gastroparesis is a gastrointestinal motor disorder characterized by a delay in gastric emptying without evidence of mechanical obstruction. Data pertaining to the demographic and clinical characteristics of gastroparesis in the Canadian population is sparse. Aims To review the authors’ experience with gastroparesis. Methods This is a retrospective observational study conducted at the Hôpital Maisonneuve-Rosemont, a tertiary care center affiliated with the University of Montréal. We collected clinical data from all patients who had a diagnosis of gastroparesis confirmed by gastric emptying scintigraphy from January 2017 to December 2019. The authors reviewed medical records for details on gastroparesis etiologies, response to pharmacologic and non-pharmacologic treatment. Results 80 patients met the inclusion criteria. 66,8% of them were females. Average age was 62,4 ± 15,7 years. The most frequently identified etiologies of gastroparesis were idiopathic (36.3%), type 1 and 2 diabetes (40%) and medication-induced (23.8%). 82.8% of idiopathic cases were women. 56.6% of patients achieved complete resolution of symptoms with only one pharmacological agent. Response to pharmacologic treatment were mixed, with domperidone and prucalopride having the highest rates of complete resolution of symptoms. Simultaneous use of 2 pharmacologic agents was attempted in 14 patients, half of which achieved resolution of symptoms. All of these patients had at least partial amelioration of their symptoms with the addition of another pharmacologic treatment. Few patients were referred to a dietician, but 66,7% clinically improved with nutritional counselling. Non-pharmacologic approach alone (nutrition consultation, counselling from the physician, withdrawal of causal medication) leads to at least partial amelioration of symptoms in 77,8% of patients. Conclusions Diabetic gastroparesis represents the most frequent cause of gastroparesis in our study, with a significant female preponderance. Improvement in symptoms was associated with the use non-pharmacological interventions, as well as simultaneous use of two pharmacological agents. Funding Agencies None
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".