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Record W4212983870 · doi:10.1038/s41386-022-01293-6

Association of locus coeruleus integrity with Braak stage and neuropsychiatric symptom severity in Alzheimer’s disease

2022· article· en· W4212983870 on OpenAlexafffund
Clifford Cassidy, Joseph Therriault, Tharick A. Pascoal, Victoria Cheung, Mélissa Savard, Lauri Tuominen, Mira Chamoun, Adelina McCall, Seyda Celebi, Firoza Z Lussier, Gassan Massarweh, Jean‐Paul Soucy, David Weinshenker, Christine Tardif, Zahinoor Ismail, Serge Gauthier, Pedro Rosa‐Neto

Bibliographic record

VenueNeuropsychopharmacology · 2022
Typearticle
Languageen
FieldMedicine
TopicAlzheimer's disease research and treatments
Canadian institutionsHotchkiss Brain InstituteUniversity of CalgaryMcGill UniversityCentre Intégré Universitaire de Santé et de Services Sociaux du Saguenay–Lac-Saint-JeanDouglas Mental Health University InstituteRoyal Ottawa Mental Health CentreCentres Intégré Universitaires de Santé et de Services SociauxMontreal Neurological Institute and HospitalCentre Intégré Universitaire de Santé et de Services Sociaux du Centre-Sud-de-l'Île-de-MontréalMcGill University Health CentreUniversity of Ottawa
FundersFonds de Recherche du Québec - SantéCanadian Institutes of Health ResearchGovernment of CanadaCerveau TechnologiesConsortium canadien en neurodégénérescence associée au vieillissementWeston Brain InstituteMcGill UniversityAlzheimer's Association
KeywordsLocus coeruleusPittsburgh compound BPsychologyNeuromelaninPathophysiologyInternal medicineNeuroimagingMagnetic resonance imagingMedicineAlzheimer's diseasePathologyNeuroscienceDiseaseCentral nervous systemParkinson's diseaseSubstantia nigraRadiology

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.006
Threshold uncertainty score0.806

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.001
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.020
GPT teacher head0.322
Teacher spread0.302 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations95
Published2022
Admission routes2
Has abstractno

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