P508. Vedolizumab for the Treatment of Fistulising Crohn's Disease: An Exploratory Analysis of Data From GEMINI 2
Bibliographic record
Abstract
also assessed by standardized scales.Clinical and demographic data were obtained from our database and the electronic medical records .Univariate analyses and multiple linear regression analysis were performed to identify predictors associated with HRQOL.Results: 91.3%(200/219) of patients included completed the questionnaires.The prevalence of anxiety and depression in our study population were 24%(48/200) and 16%(32/200).Univariate analyses showed that anxiety symptoms, depression symptoms , perceived stress , perceived social support ,disease activity , previous hospitalizations and relapses, hemoglobin and medical costs were strongly or moderatly correlated with HRQOL.Multivariate regression analysis revealed that both disease activity and anxiety symptoms were strong predictors of impaired HRQOL.Conclusions: Our study demonstrates that psychological disorder contributes to impaired HRQOL in IBD, independent of the disease activity.Therefore, psychological distress should be considered in our current management of IBD patients and appropriate psychotherapy may improve HRQOL of these individuals.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.002 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".