QUALITY OF LIFE AND CAREGIVER BURDEN IN MULTIPLE MYELOMA AND LYMPHOMA PATIENTS AND THEIR CAREGIVERS UNDERGOING OUTPATIENT AUTOLOGOUS STEM CELL TRANSPLANTATION COMPARED TO INPATIENT TRANSPLANTATION
Bibliographic record
Abstract
IntroductionThe outpatient setting has now become a standard alternative to the traditional inpatient approach for autologous stem cell transplantation (ASCT) for multiple myeloma and lymphoma. Outpatient ASCT involves family/friends assuming round-the-clock caregiving responsibilities, and though it is perceived as potentially providing superior patient quality of life (QOL), supporting evidence is limited. Furthermore, little is known about caregiver QOL and lost opportunity costs (wages/travel time). Our objectives were to compare QOL of patients and their caregivers in the inpatient vs outpatient settings, and to delineate costs.MethodsPatients completed 4 questionnaires (FACT-BMT, FACT-Fatigue, EQ5D, and distress impact), and caregivers completed 3 questionnaires (C-QOLC, distress impact, and financial impact). The timepoints were: D0 (baseline), D+7, D+14, D+28 and D+100.ResultsIn total, 52 patients and 51 caregivers enrolled (21 inpatients/31 outpatients). Patientsu2019 median age was 57 (range: 18-70), and 67% male. Majority of caregivers were spouses (73%). In the overall population, FACT-BMT scores significantly declined at D+7, then increased to above-baseline by D+100. FACT-Fatigue worsened significantly at D+7, then improved to lower than baseline at D+100. Additionally, EQ5D scores (imaginable health status) significantly declined at D+7 and D+14, then increased to above baseline at D+100 (albeit p>0.05). QOL scores were insignificant when comparing inpatients vs. outpatients, though trends still existed. Caregiver QOL scores were consistently higher for inpatients, though insignificant. Average lost opportunity costs for caregivers was $4195.ConclusionsThere was significant deterioration of various aspects of QOL in the overall population. Inpatient caregivers report better QOL than outpatients, though sample size limits further analyses.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.001 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.003 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".