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Record W4214608552 · doi:10.53879/id.58.08.p0005

COMBINATORIAL DRUGS

2021· article· en· W4214608552 on OpenAlexaboutno aff

Bibliographic record

VenueINDIAN DRUGS · 2021
Typearticle
Languageen
FieldMedicine
TopicPharmaceutical Practices and Patient Outcomes
Canadian institutionsnot available
Fundersnot available
KeywordsBlood pressurePillMedicinePopulationQuarter (Canadian coin)Internal medicinePharmacologyGeographyEnvironmental health

Abstract

fetched live from OpenAlex

At the University of Sydney’s Westmead Applied Research Center in Australia, Professor Clara Chow's team has discovered in a long-duration study that a combination of four drugs commonly used to treat blood pressure - at only a quarter of their usual doses - is much more effective in getting blood pressure under control compared to the standard treatment with one or two drugs. The new combination could remarkably bring the blood pressure under control in 80% of the participants within 12 weeks. The four drugs were given in the form of a pill. Apart from the lower concentrations of the drugs required, ease of administering and patient compliance of the new quadruple strategy are obvious additional advantages. This discovery, published recently in Lancet, might contribute to basic changes in the management of patients having high blood pressure. Professor Chow laments that control of hypertension is not ideal anywhere, and in some regions such as Africa fewer than one in ten have it under control. The prevalence of hypertension is expected to increase to 29%(!) of the global population in four years from now

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.897
Threshold uncertainty score1.000

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.050
GPT teacher head0.367
Teacher spread0.317 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

Study designNot applicable
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes1
Has abstractyes

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