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Evaluation of Lipid Profile in Patients with Cardiovascular Diseases Receiving Simvastatin in Palu Indonesia

2018· article· en· W4214616504 on OpenAlexvenueno aff
Rudi Safarudin, Alwiyah Mukaddas, Faraditha Amalia, Amelia Rumi

Bibliographic record

VenueJournal of Pharmacy and Nutrition Sciences · 2018
Typearticle
Languageen
FieldComputer Science
TopicComputational Drug Discovery Methods
Canadian institutionsnot available
FundersUniversitas Tadulako
KeywordsSimvastatinMedicineLipid profileInternal medicineCholesterolBlood lipidsInclusion and exclusion criteriaCause of deathStatinPathologyDisease

Abstract

fetched live from OpenAlex

Cardiovascular diseases (CVDs) are the leading cause of death worldwide which results from the impaired function of the heart and blood vessels. The most common CVDs are coronary heart and stroke. The main clinical manifestation of these diseases is the formation of atherosclerosis which is associated with the change of blood lipid levels. Simvastatin is widely used in patients with impaired lipid levels in the blood. The study was a descriptive research with a retrospective approach on medical record data (n=64) taken from Palu City, Central Sulawesi, Indonesia. The variables included in this study were gender, age, diagnosis, co-medication, lipid profile including total cholesterol, LDL, triglycerides, and HDL in patients with CVDs receiving simvastatin. In the study, sixty-four patients of CVDs met the inclusion and exclusion criteria. This study suggested that simvastatin achieved to normalize the blood lipid levels, including total cholesterol in forty-four patients (68.75%), LDL in forty-nine patients (80.3%), triglycerides in fifty-nine patients (92.19%), and HDL in fifty-two patients (81.25%). The use of simvastatin in patients with CVDs managed to lower total cholesterol, LDL, and triglycerides, as well as increase the HDL level.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.003
Threshold uncertainty score0.005

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.046
GPT teacher head0.357
Teacher spread0.311 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations1
Published2018
Admission routes1
Has abstractyes

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