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Record W4214884231 · doi:10.1017/9781108975759.041

Alzheimer’s Disease Neuroimaging Initiative

2022· book-chapter· en· W4214884231 on OpenAlexfundno aff
Charles Bernick

Bibliographic record

VenueCambridge University Press eBooks · 2022
Typebook-chapter
Languageen
FieldMedicine
TopicDementia and Cognitive Impairment Research
Canadian institutionsnot available
FundersAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General HospitalAvid RadiopharmaceuticalsUniversity of California, San FranciscoNational Institutes of HealthIpsenDaiichi Sankyo EuropeServierTel Aviv UniversityBayer HealthCareKorean Neurological AssociationMcGill UniversityMultiple Sclerosis SocietyUniversity of PittsburghU.S. Social Security AdministrationJohns Hopkins UniversitySPIESynarcMontreal Neurological Institute and HospitalHarvard UniversityAmerican Academy of NeurologyPfizerYork UniversityBiogenMassachusetts General HospitalAstraZenecaU.S. Department of DefenseEli Lilly and CompanySiemensTauRx PharmaceuticalsHôpitaux Universitaires de GenèveAlzheimer's AssociationCentre d'Imagerie BioMédicaleWashington University in St. LouisMassachusetts Institute of TechnologyComputer Science and Artificial Intelligence Laboratory, Massachusetts Institute of TechnologyUniversity of California, San DiegoU.S. Department of Veterans AffairsBrigham and Women's Hospital
KeywordsNeuroimagingNeuroscienceDiseaseMedicineAlzheimer's Disease Neuroimaging InitiativePsychologyAlzheimer's diseaseInternal medicine

Abstract

fetched live from OpenAlex

The Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a longitudinal, observational study initiated in 2004 with the aim to develop and validate biomarkers for Alzheimer’s disease (AD) trials. From its inception, ADNI has been a model of a public–private partnership, with industry partners involved not only through financial support but in a guidance capacity. Through the development of standardized methods, ADNI has collected imaging and fluid biomarker data from cognitively normal, early and late mild cognitive impairment, and AD participants which is available to qualified researchers without embargo. Moreover, these methods have been incorporated into companion studies worldwide. The data that have been collected have provided important insights into the progression of AD pathology over time, assists in understanding which biomarkers may be most useful in clinical trials and have facilitated the design of studies of disease-modifying therapies.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.077
Threshold uncertainty score0.259

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0010.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0020.002
Science and technology studies0.0010.001
Scholarly communication0.0030.003
Open science0.0010.002
Research integrity0.0020.004
Insufficient payload (model declined to judge)0.0770.086

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.056
GPT teacher head0.269
Teacher spread0.213 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations58
Published2022
Admission routes1
Has abstractyes

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