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Virtual Ontogeny of Cortical Growth Preceding Mental Illness

2022· article· en· W4214903121 on OpenAlexafffund
Yash Patel, Jean Shin, Christoph Abé, Ingrid Agartz, Clara Alloza, Dag Alnæs, Sonia Ambrogi, Linda A. Antonucci, Celso Arango, Volker Arolt, Guillaume Auzias, Rosa Ayesa‐Arriola, Nerisa Banaj, Tobias Banaschewski, Cibele Edom Bandeira, Zeynep Başgöze, Renata B. Cupertino, Claiton H.D. Bau, Jochen Bauer, Sarah Baumeister, Fabio Bernardoni, Alessandro Bertolino, Caterina del Mar Bonnín, Daniel Brandeis, Silvia Brem, Jason Bruggemann, Robin Bülow, Juan Bustillo, Sara Calderoni, Rosa Calvo, Erick J. Canales‐Rodríguez, Dara M. Cannon, Susanna Carmona, Vaughan J. Carr, Stanley V. Catts, Sneha Chenji, Qian Hui Chew, David Coghill, Colm G. Connolly, Annette Conzelmann, Alexander R. Craven, Benedicto Crespo‐Facorro, Kathryn R. Cullen, Andreas Dahl, Udo Dannlowski, Christopher G. Davey, Christine Deruelle, Covadonga M. Díaz‐Caneja, Katharina Dohm, Stefan Ehrlich, Jeffery N. Epstein, Tracy Erwin-Grabner, Lisa T. Eyler, Jennifer Fedor, Jacqueline Fitzgerald, Will Foran, Judith M Ford, Lydia Fortea, Paola Fuentes‐Claramonte, Janice M. Fullerton, Lisa S. Furlong, Louise Gallagher, Bingchen Gao, Si Gao, José Manuel Goikolea, Ian H. Gotlib, Roberto Goya‐Maldonado, Hans J. Grabe, Melissa J. Green, Eugênio H. Grevet, Nynke A. Groenewold, Dominik Grotegerd, Oliver Gruber, Jan Haavik, Tim Hahn, Ben J. Harrison, Walter Heindel, Frans Henskens, Dirk J. Heslenfeld, Eva Hilland, Pieter J. Hoekstra, Sarah Hohmann, Nathalie Holz, Fleur M. Howells, Jonathan Ipser, Neda Jahanshad, Babette Jakobi, Andreas Jansen, Joost Janssen, Rune Jonassen, Anna Kaiser, Vasiliy G. Kaleda, James A. Karantonis, Joseph A. King, Tilo Kircher, Peter Kochunov, Sheri‐Michelle Koopowitz, Mikael Landén, Nils Inge Landrø, Stephen M. Lawrie, И. С. Лебедева, Beatriz Luna, Astri J. Lundervold, Frank P. MacMaster, Luigi A. Maglanoc, Daniel H. Mathalon, Colm McDonald, Andrew M. McIntosh, Susanne Meinert, Patricia T. Michie, Philip B. Mitchell, Ana Moreno‐Alcázar, Bryan Mowry, Filippo Muratori, Leila Nabulsi, Igor Nenadić, Ruth Tuura, Jaap Oosterlaan, Bronwyn J. Overs, Christos Pantelis, Mara Parellada, José C. Pariente, Paul Pauli, Giulio Pergola, Francesco Maria Piarulli, Felipe Almeida Picon, Fabrizio Piras, Edith Pomarol‐Clotet, Clara Pretus, Yann Quidé, Joaquim Raduà, Josep Antoni Ramos‐Quiroga, Paul E. Rasser, Andreas Reif, Alessandra Retico, Gloria Roberts, Susan L. Rossell, Diego Luiz Rovaris, Katya Rubia, Matthew D. Sacchet, Josep Salavert, Raymond Salvador, Salvador Sarró, Akira Sawa, Ulrich Schall, Rodney J. Scott, Pierluigi Selvaggi, Timothy J. Silk, Kang Sim, Antonín Škoch, Gianfranco Spalletta, Filip Španiel, Dan J. Stein, Olaf Steinsträter, Aleks Stolicyn, Yoichiro Takayanagi, Leanne Tamm, Maria Eduarda Tavares, Alexander Teumer, Katharina Thiel, Sophia I. Thomopoulos, David Tomeček, A. S. Tomyshev, Diana Tordesillas‐Gutiérrez, Michela Tosetti, Anne Uhlmann, Tamsyn E. Van Rheenen, Javier Vázquez-Bourgón, Meike W. Vernooij, Eduard Vieta, Óscar Vilarroya, Cynthia Shannon Weickert, Thomas W. Weickert, Lars T. Westlye, Heather C. Whalley, David Willinger, Alexandra Winter, Katharina Wittfeld, Tony T. Yang, Yuliya Yoncheva, Jendé L. Zijlmans, Martine Hoogman, Barbara Franke, Daan van Rooij, Jan K. Buitelaar, Christopher R. K. Ching, Ole A. Andreassen, Elena Pozzi, Dick J. Veltman, Lianne Schmaal, Theo G.M. van Erp, Jessica Turner, F. Xavier Castellanos, Zdenka Pausová, Paul M. Thompson, Tomáš Paus

Bibliographic record

VenueBiological Psychiatry · 2022
Typearticle
Languageen
FieldMedicine
TopicAdvanced Neuroimaging Techniques and Applications
Canadian institutionsUniversité de MontréalUniversity of CalgaryCentre Hospitalier Universitaire Sainte-JustineUniversity of TorontoSickKids FoundationHospital for Sick Children
FundersCilagSingapore Bioimaging ConsortiumScottish Mental Health Research NetworkNational Center for Complementary and Integrative HealthNational Institute on Drug AbuseEuropean Regional Development FundH2020 Marie Skłodowska-Curie ActionsHorizon 2020Medizinische Fakultät, Westfälische Wilhelms-Universität MünsterInstituto de Salud Carlos IIINational Health and Medical Research CouncilNational Center for Advancing Translational SciencesSeventh Framework ProgrammeNIH Clinical CenterRamsay Health CareNational Institute on Alcohol Abuse and AlcoholismStiftelsen för Strategisk ForskningMedical Research CouncilSiemens HealthineersInnovative Medicines InitiativeInterdisziplinäres Zentrum für Klinische Forschung, Universitätsklinikum WürzburgHartmann Müller-Stiftung für Medizinische ForschungMedical Research Council CanadaUniversity of Cape TownCentro de Investigación Biomédica en Red de Salud MentalSociety for Mental Health ResearchNational Institute of Neurological Disorders and StrokeUniversität ZürichAustralian Schizophrenia Research BankNorges ForskningsrådMinisterio de Ciencia e InnovaciónMeath FoundationClinical and Translational Science Institute, University of California, San FranciscoNational Institute of Mental HealthHelse Sør-Øst RHFHospital de Clínicas de Porto AlegreBrain and Behavior Research FoundationConselho Nacional de Desenvolvimento Científico e TecnológicoCentre of Excellence in Cognition and its Disorders, Australian Research CouncilMinistero della SaluteMacquarie UniversityGeneralitat de CatalunyaNatural Sciences and Engineering Research Council of CanadaAmerican Foundation for Suicide PreventionBundesministerium für Bildung und ForschungCoordenação de Aperfeiçoamento de Pessoal de Nível SuperiorDeutsche ForschungsgemeinschaftNederlandse Organisatie voor Wetenschappelijk OnderzoekNational Institute of Biomedical Imaging and BioengineeringUniversity of MelbourneStiftelsen för Strategisk ForskningNational Institute for Health and Care ResearchNational Research FoundationSouth African Medical Research CouncilSwinburne University of TechnologyMinisterio de Ciencia, Innovación y UniversidadesHealth Research BoardPratt FoundationCentres de Recerca de CatalunyaNational Institutes of HealthChildren's Hospital FoundationFundação Instituto de Pesquisas EconômicasWellcome TrustUniversity of California, San FranciscoSimons Foundation Autism Research InitiativeSchizophrenia Research FundSylvia and Charles Viertel Charitable FoundationAustralian Research CouncilFresenius Medical Care North AmericaNational Institute on AgingJack Brockhoff FoundationEU Joint Programme – Neurodegenerative Disease ResearchBill and Melinda Gates FoundationNational Center for Research ResourcesNational Alliance for Research on Schizophrenia and DepressionBiogenHjärnfondenMinisterstvo Zdravotnictví Ceské RepublikyEuropean CommissionRussian Foundation for Basic ResearchNational Healthcare GroupEuropean Federation of Pharmaceutical Industries and AssociationsCarnegie Corporation of New YorkChiropractic and Osteopathic College of AustralasiaCollier Charitable FundIndiana Clinical and Translational Sciences InstituteAutism SpeaksFundação de Amparo à Pesquisa do Estado do Rio Grande do SulHorizon 2020 Framework ProgrammeVetenskapsrådetUniversity of MinnesotaSchweizerischer Nationalfonds zur Förderung der Wissenschaftlichen ForschungU.S. Department of Veterans Affairs
KeywordsDISC1Schizophrenia (object-oriented programming)Neurodevelopmental disorderPsychosisCerebral cortexNeurosciencePsychologyAutismBiologyGenePsychiatryGenetics

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: Observational
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.164
Threshold uncertainty score0.287

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.076
GPT teacher head0.353
Teacher spread0.277 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

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Citations35
Published2022
Admission routes2
Has abstractno

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