CNS volume 11 issue 9 Cover and Front matter
Bibliographic record
Abstract
Important Safety Information: Daytrana should not be used in patients with allergy to methylphenidate or patch components; marked anxiety, tension and agitation; glaucoma; tics, diagnosis or a family history of Tourette's syndrome; seizures; or during or within 14 days after treatment with monoamine oxidase inhibitors (MAOIs).Sudden death has been reported in association with CNS stimulant treatment at usual doses in children and adolescents with structural cardiac abnormalities or other serious heart problems.Sudden deaths, stroke, and myocardial infarction have been reported in adults taking stimulant drugs at usual doses in ADHD.Physicians should take a careful patient history, including family history, and physical exam to assess the presence of cardiac disease.Patients who report symptoms of cardiac disease such as exertional chest pain and unexplained syncope should be promptly evaluated.Use with caution in patients whose underlying medical condition might be affected by increases in blood pressure or heart rate.New psychosis, mania, aggression, growth suppression, and visual disturbances have been associated with the use of stimulants.Use with caution in patients with a history of: psychosis; EEG abnormalities; bipolar disorder; depression.Growth and hematologic monitoring is advised during prolonged treatment.Patients should avoid applying external heat to the Daytrana patch.Skin irritation or contact sensitization may occur.Daytrana should be given cautiously to patients with a history of drug dependence and alcoholism.Chronic abuse can lead to marked tolerance and psychological dependence.Frank psychotic episodes can occur, especially with parenteral abuse.Careful supervision is required during withdrawal from abusive use, since severe depression may occur.Withdrawal following chronic therapeutic use may unmask symptoms of the underlying disorder.Common adverse events reported by patients who received Daytrana in clinical trials were decreased appetite, insomnia, nausea, vomiting, decreased weight, tics, affect lability, and anorexia, consistent with adverse events commonly associated with the use of methylphenidate. Please see Brief Summary of Prescribing Information on adjacent page, including Boxed Warning.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.001 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.002 | 0.001 |
| Insufficient payload (model declined to judge) | 0.539 | 0.293 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; the direct Gemma label and the distilled Codex classifier agree on what is shown here.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".