MétaCan
Menu
Back to cohort
Record W4220950765 · doi:10.1016/j.jbc.2022.101871

Characterization of a phylogenetically distinct extradiol dioxygenase involved in the bacterial catabolism of lignin-derived aromatic compounds

2022· article· en· W4220950765 on OpenAlex
Laura E. Navas, Michael Zahn, Harbir Bajwa, J.C. Grigg, Megan E Wolf, Anson Chan, M.E.P. Murphy, J.E. McGeehan, Lindsay D. Eltis

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

affAt least one author lists a Canadian institution in the pinned OpenAlex snapshot.
fundA Canadian funder is recorded on the work.

Bibliographic record

VenueJournal of Biological Chemistry · 2022
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicBiochemical and biochemical processes
Canadian institutionsUniversity of British Columbia
FundersNational Research Council CanadaResearch EnglandNatural Sciences and Engineering Research Council of CanadaCanadian Institutes of Health ResearchUniversity of SaskatchewanCanadian Light Source
KeywordsCatabolismChemistryLigninDioxygenaseGuaiacolCatecholStereochemistryRhodococcusBiochemistryBiphenylEnzyme kineticsEnzymeOrganic chemistryActive site

Abstract

fetched live from OpenAlex

The actinobacterium Rhodococcus jostii RHA1 grows on a remarkable variety of aromatic compounds and has been studied for applications ranging from the degradation of polychlorinated the of of the of of and a the of RHA1 for and for the for the of and and the of the the the a and the a RHA1 grows on a of and and the of the of the of the of aromatic compounds from and the of The actinobacterium Rhodococcus jostii RHA1 grows on a remarkable variety of aromatic compounds and has been studied for applications ranging from the degradation of polychlorinated the of of the of of and a the of RHA1 for and for the for the of and and the of the the the a and the a RHA1 grows on a of and and the of the of the of the of aromatic compounds from and the of The of aromatic compounds has been studied for the of polychlorinated the of a for a aromatic and the a of aromatic compounds and of a of of and Rhodococcus and The of and Rhodococcus and The and The of aromatic for of and a of aromatic compounds The of of aromatic jostii RHA1 a for a variety of the of aromatic compounds and the of a of Rhodococcus RHA1 a a Rhodococcus from RHA1 from for remarkable polychlorinated the Rhodococcus the and and of degradation of polychlorinated The of RHA1 of the polychlorinated the Rhodococcus of of a Rhodococcus the of the the of a RHA1 of the of Rhodococcus the aromatic compounds the of and Rhodococcus and and and Rhodococcus jostii of for the of the of the on of compounds the of and of for the of of Rhodococcus a has on the of a for and of the of a a of for the of of Rhodococcus a the been of a Rhodococcus of the of Rhodococcus and for a has been and of the from the and a The and of RHA1 a and of for the of RHA1 the the of the the of the of a of studied from RHA1 the of the of and the of aromatic compounds the for and a of the of and for and studied the of RHA1 on a of and and the the of and of the of aromatic the and the of and and the and and of the of the and The and of of the The of a and a The of the of for the of the of the a and the of of of of of the of on the of the of the of the of the a of and the of a variety of for and for for the the of the been of a Rhodococcus of the of Rhodococcus the of a the of the of the the the of has a of of a a the degradation of polychlorinated The of on the of Rhodococcus a of a a the degradation of polychlorinated of the a the of aromatic compounds and the on the of for for of of and of for for The the and of The of and of for for The the and of a the from the of of and of the of the on the from a of the of of The from and the of the of The from the of and for The of the for a the and the of the on the for and the of the of for of for the of the of of the of and the the the a of the and and the the the a of the and a The of of the the of from a and the for of from Rhodococcus for and a the and The and the the a the from and the of and the the and a the The of and the the and and for of from and the the for and the for the a the and a the a The a the the the and the the of the The from a and and and of and of and and the of the of The and and of of for of from and of of the and of the of the on of and a of a for polychlorinated the of and the of the of of and and for and of the of the the and the of the and the of the a the of the the from the from the the from the and The of the a the of the of and the of the the the the of the and the the of the and the a and the the a and of a for and of the of the the the the and of the of the the the and and of and RHA1 and the a of and on and the the on of of the the aromatic compounds on the the the of and the and on and a of a and the of RHA1 of and Rhodococcus and The on on the on the of RHA1 on a of and of and RHA1 on of RHA1 on a of and on of the and of of and RHA1 on on a of and the and of the of the the of the of and the of of RHA1 the of and on the of and Rhodococcus and on the on the and the and on the of and a RHA1 and of from RHA1 on and on of the a of the and the The of and the of the of and from on of the a of the and the The of and the of the of and from a has a for of the the of and jostii RHA1 of for the of of Rhodococcus a of the the of and the a the The and the from the The of a of of the and from and and of from the degradation of and for from for the and of the of for of of for the of has for a of for and of the from a degradation from the of a of the from for the of and for and the of of the of the a of the of for for of from and The of the The and of and and the of and of the and and the the of the a the of of for The of for the of the the has for and a for of a for polychlorinated The of and from the and the for of the the RHA1 aromatic compounds and on a of and and the for on the and and the of of the of and a the the of for of for for the and of and and a the the of a and a of the a the of aromatic compounds and of from for and of for the of for a a of and The the on the The of from and of for the of of the of and the for from of of and from the the The a The the for The and the the and for the and of and and a The of for The the a of The a from the and of the and of and a a and from the the the on and a of from a a a and a and of a of from the of a the of a and and the of of the for and of the of of the the the of of the the the and and the for the the a and the a and a of The of the the and the the of and on the the of the The and The the of the of the the the of and a a the of The of the of and the from the and the the the and and a The on a a a a of and the of RHA1 of The of and on a a and the the and The of the and the of of and a and of the and from a and for and for a on the on and and The for and of a a the The from the the and the and the and of and the for the of the and and for the and for and The been the and the for the and the of of for and for the of for and for for the for the a and RHA1 and and of of RHA1 and for the and of and from and the a and a the of the RHA1 and on from and a of a the for and a and for The the the of RHA1 for and a The from a of compounds RHA1 and of Rhodococcus a and of and Rhodococcus and and for and and and of on a a and on from on and and The for and the a The of and The and of for a been the and the for of from Rhodococcus of a for polychlorinated the and from and of from the degradation of and and of from the degradation of and The of aromatic compounds has been studied for the of polychlorinated the of a for a aromatic and the a of aromatic compounds and of a of of and Rhodococcus and The of and Rhodococcus and The and The of aromatic for of and a of aromatic compounds The of of aromatic Rhodococcus jostii RHA1 a for a variety of the of aromatic compounds and the of a of Rhodococcus RHA1 a a Rhodococcus from RHA1 from for remarkable polychlorinated the Rhodococcus the and and of degradation of polychlorinated The of RHA1 of the polychlorinated the Rhodococcus of of a Rhodococcus the of the the of a RHA1 of the of Rhodococcus the aromatic compounds the of and Rhodococcus and and and Rhodococcus jostii of for the of the of the RHA1 on of compounds the of and of for the of of Rhodococcus a has on the of a for and of the of a a of for the of of Rhodococcus a the been of a Rhodococcus of the of Rhodococcus and for a has been and of the from the and a The and of RHA1 a and of for the of RHA1 the the of the the of the of a of studied from RHA1 the of the of and the of aromatic compounds the for and a of the of and for and studied the of RHA1 on a of and and the the of and of the of aromatic the and the of and and the and and of the of the and The and of of the The of a and a The of the of for the of the of the a and the of of of of of the of on the of the of the of the of the a of and the of a variety of for and for for the the of the been of a Rhodococcus of the of Rhodococcus the of a the of the of the the the of has a of of a a the degradation of polychlorinated The of on the of Rhodococcus a of a a the degradation of polychlorinated of the a the of aromatic compounds and the on the of for for of of and of for for The the and of The of and of for for The the and of a the from the of of and of the of the on the from a of the of of The from and the of the of The from the of and for The of the for a the and the of the on the for and the of the of for of for the of the of of the of and the the the a of the and and the the the a of the and a The of of the the of from a and the for of from Rhodococcus for and a the and The and the the a the from and the of and the the and a the The of and the the and and for of from and the the for and the for the a the and a the a The a the the the and the the of the The from a and and and of the and of the of the on of and a of a for polychlorinated the of and the of the of of and and for and of the of the the and the of the and the of the a the of the the from the from the the from the and The of the a the of the of and the of the the the the of the and the the of the and the a and the the a and of a for and of the of the the the the and of the of the the the and and of and RHA1 and the a of and on and the the on of of the the aromatic compounds on the the the of and the and on and a of a and the of RHA1 of and Rhodococcus and The on on the on the of RHA1 on a of and of and RHA1 on of RHA1 on a of and on of the and of of and RHA1 on on a of and the and of the of the the of the of and the of of RHA1 the of and on the of and Rhodococcus and on the on the and the and on the of and a RHA1 and of from RHA1 on and on of the a of the and the The of and the of the of and from on of the a of the and the The of and the of the of and from a the and the of and and the and and of the of the and The and of of the The of a and a The of the of for the of the the and the of and and the and and of the of the and The and of of the The of a and a The of the of for the of the of the a and the of of of of of the of on the of the the a and the of of of of of the of on the of the The of the of the of the a of and the of a variety of for and for for the the of the been of a Rhodococcus of the of Rhodococcus the of a the of the of the the the of has a of of a a the degradation of polychlorinated The of on the of Rhodococcus a of a a the degradation of polychlorinated of the a the of aromatic compounds and the on the of for for of of and of for for The the and of The of and of for for The the and of a the from the of of and of the of the on the from a of the of of The from and the of the of The from the of and for The of the the of the of the a of and the of a variety of for and for for the the of the been of a Rhodococcus of the of Rhodococcus the of a the of the of the the the of has a of of a a the degradation of polychlorinated The of on the of Rhodococcus a of a a the degradation of polychlorinated of the a the of aromatic compounds and the on the of for for the from the of of and of the of the on the from a of the of of The from and the of the of The from the of and for The of the for a the and the of the on the for and the of the of for of for the of the of of the of and the the the a of the and and the the the a of the and a for a the and the of the on the for and the of the of for of for the of the of of the The of of the the of from a and the for of from Rhodococcus for and a the and The and the the a the from and the of and the the and a the The of and the the and and for of from and the the for and the for the a the and a the a The a the the the and the the of the The from a and and and The of the the of from a and the for of from Rhodococcus for and a the and The and the the a the from and the of and the the and a the The of and the the and and for of from and the the for and the for the a the and a the a The a the the the and the the of the The from a and and and The of the and of the of the on of and a of a for polychlorinated the of and the of the of of and and for and of the of the the and the of the and the of the a the of the the from the from the the from the and The of the a the of the of and the of the the the the of the and the the of the and the a and the the a and of a the of the on of and a of a for polychlorinated the of and the of the of of and and for and of the of the the and the of the and the of the a the of the the from the from the the from the and The of the a the of the of and the of the the the the of the and the the of the and the a and the the a and of a of and RHA1 and the a of and on and the the on of of the the aromatic compounds on the the the of and the and on and a of a and the of RHA1 of and Rhodococcus and The on on the on the of RHA1 on a of and the of the the of the of and the of of RHA1 the of and on the of and Rhodococcus and on the on the and the and on the of and a RHA1 and of from RHA1 on and on of the a of the and the The of and the of the of and from on of the a of the and the The of and the of the of and from a RHA1 and the a of and on and the the on of of the the aromatic compounds on the the the of and the and on and a of a and the of RHA1 of and Rhodococcus and The on on the on the of RHA1 on a of and the of the the of the of and the of of RHA1 the of and on the of and Rhodococcus and on the on the and the and on the of and a RHA1 and has a for of the the of and jostii RHA1 of for the of of Rhodococcus a of the the of and the a the The and the from the The of a of of the and from and and of from the degradation of and for from for the and of the of for of of for the of has for a of for and of the from a degradation from the of a of the from for the of and for and the of of the of the a of the of for for of from and The of the The and of and and the of and of the and and the the of the a the of of for The of for the of the the has for and a for of a for polychlorinated The of and from the and the for of the the RHA1 aromatic compounds and on a of and and the for on the and and the of of the of and a the the of for of for for the and of and and a the the of a and a of the a the of aromatic compounds has a for of the the of and jostii RHA1 of for the of of Rhodococcus a of the the of and the a the The and the from the The of a of The of the and from and and of from the degradation of and for from for the and of the of for of of for the of has for a of for and of the from a degradation from the of a of the from The for the of and for and the of of the of the a of the of for for of from and The of the The and of and and the of and of the and and the the of the a the of of for The of for the of the the has for and a for of a for polychlorinated The of and from the and the for of the the The RHA1 aromatic compounds and on a of and and the for on the and and the of of the of and a the the of for of for for the and of and and a the the of a and a of the a the of aromatic compounds and of from for and of for the of for a a of and The the on the The of from and of for the of of the of and the for from of of and from the the The a The the for The and the the and for the and of and and a The of for The the a of The a from the and of the and of and a a and from the the the on and a of from a a a and a and of a of from the of a the of a and and the of of the for and of the of of the the the of of the the the and and the for the the a and the a and a of The of the the and the the of and on the the of the The and The the of the of the the the of and a a the of The of the of and the from the and the the the and and a The on a a a a of and the of RHA1 of The of and on a a and the the and The of the and the of of and a and of the and from a and for and for a on the on and and The for and of a a the The from the the and the and the and of and the for the of the and and for the and for and The been the and the for the and the of of for and for the of for and for for the for the a and RHA1 and and of of RHA1 and for the and of and from and the a and a the of the RHA1 and on from and a of a the for and a and for The the the of RHA1 for and a The from a of compounds RHA1 and of Rhodococcus a and of and Rhodococcus and and for and and and of on a a and on from on and and The for and the a The of and The and of for a and of from for and of for the of for a a of of from for and of for the of for a a of and The the on the The of from and The the on the The of from and of for the of of the of and the for from of of and from the the The a The the for The and the the and for the and of of for the of of the of and the for from of of and from the the The a The the for The and the the and for the and of and and a The of for The the a of The a from the and of the and of and a a and from the the the on and a and a The of for The the a of The a from the and of the and of and a a and from the the the on and a of from a a a and a and of a of from of from a a a and a and of a of from the of a the of a and and the of of the for and of the of of the the the of of the the the and and the for the the a and the a and a of The of the the and the the of and on the the of the The and The the of the of the the the of and a a the of The of the of and the from the and the the the and and a The on a a a a of and the of RHA1 of The of and on a a and the the and The of the and the of of the of a the of a and and the of of the for and of the of of the the the of of the the the and and the for the the a and the a and a of The of the the and the the of and on the the of the The and The the of the of the the the of and a a the of The of the of and the from the and the the the and and a The on a a a a of and the of RHA1 of The of and on a a and the the and The of the and the of of and a and of the and from a and for and for a on the on and and The for and of a a the The from the the and the and the and of and the for the of the and and for the and for and The been the and the for the and the of of for and for the of for and for for the for the a and a and of the and from a and for and for a on the on and and The for and of a a the The from the the and the and the and of and the for the of the and and for the and for and The been the and the for the and the of of for and for the of for and RHA1 and and of of RHA1 and for the and of and from and the a and a the of the RHA1 and on from and a of a the for and a and for The the the of RHA1 for and a The from a of compounds RHA1 and of Rhodococcus a and of and Rhodococcus and and for and and RHA1 and of of RHA1 and for the and of and from and the a and a the of the RHA1 and on from and a of a the for and a and for The the the of RHA1 for and a The from a of compounds RHA1 and of Rhodococcus a and of and Rhodococcus and and for and and and of on a a and on from on and and and of on a a and on from on and and The for and the a The of and The and of for a The for and the a The of and The and of for a been the and the The been the and the for of from Rhodococcus of a for polychlorinated the and from and of from the degradation of and and of from the degradation of and for of from Rhodococcus of a for polychlorinated the and from and of from the degradation of and and of from the degradation of and The of the of and the the of the the a of the of the for the and the the of the of and the of and and and and and and and the from the and of and and the of a and for

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.008
Threshold uncertainty score0.455

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0010.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.015
GPT teacher head0.223
Teacher spread0.208 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it