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Record W4221025615 · doi:10.1016/j.semcdb.2022.03.020

Brain organoids, consciousness, ethics and moral status

2022· review· en· W4221025615 on OpenAlexaff
Jacob J. Jeziorski, Reuven Brandt, John H. Evans, W. Marie Campana, Michael Kalichman, Evan Thompson, Lawrence S.B. Goldstein, Christof Koch, Alysson R. Muotri

Bibliographic record

VenueSeminars in Cell and Developmental Biology · 2022
Typereview
Languageen
FieldNeuroscience
TopicNeuroethics, Human Enhancement, Biomedical Innovations
Canadian institutionsUniversity of British Columbia
FundersNational Institute of Mental HealthNational Institutes of HealthBrain and Behavior Research FoundationCalifornia Institute for Regenerative MedicineSimons Foundation Autism Research InitiativeNational Alliance for Research on Schizophrenia and DepressionSimons Foundation
KeywordsOrganoidConsciousnessInduced pluripotent stem cellNeuroethicsNeuroscienceEnvironmental ethicsHuman brainBioethicsEngineering ethicsCognitive sciencePsychologyBiologyPolitical scienceEmbryonic stem cellLawPhilosophyEngineering

Abstract

fetched live from OpenAlex
No abstract in any covered source. Its absence is recorded, not treated as a negative.

No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.002
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Theoretical or conceptual · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.004
Threshold uncertainty score0.013

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.002
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.000
Bibliometrics0.0020.003
Science and technology studies0.0010.005
Scholarly communication0.0030.003
Open science0.0010.002
Research integrity0.0030.003
Insufficient payload (model declined to judge)0.0040.001

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.129
GPT teacher head0.371
Teacher spread0.242 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designTheoretical or conceptual
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations62
Published2022
Admission routes1
Has abstractno

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