MétaCan
Menu
Back to cohort
Record W4221065122 · doi:10.1038/s41392-022-00958-4

Correction: Activation of RAS/MAPK pathway confers MCL-1 mediated acquired resistance to BCL-2 inhibitor venetoclax in acute myeloid leukemia

2022· erratum· en· W4221065122 on OpenAlexaff
Qi Zhang, Bridget Riley‐Gillis, Lina Han, Yannan Jia, Alessia Lodi, Haijiao Zhang, Saravanan Ganesan, Rongqing Pan, Sergej Konoplev, Shannon Sweeney, Jeremy Ryan, Yulia Jitkova, Kenneth Dunner, Shaun Grosskurth, Priyanka Vijay, Sujana Ghosh, Charles Lu, Wencai Ma, Stephen E. Kurtz, Vivian Ruvolo, Helen Ma, Connie C. Weng, Cassandra L. Ramage, Natalia Baran, Tianyu Cai, R. Eric Davis, Venkata Lokesh Battula, Yingchang Mi, Jing Wang, Courtney D. DiNardo, Michael Andreeff, Jeffery W. Tyner, Aaron D. Schimmer, Anthony Letai, Rose Ann Padua, Carlos E. Bueso-Ramos, Stefano Tiziani, Joel D. Leverson, Relja Popovic, Marina Konopleva

Bibliographic record

VenueSignal Transduction and Targeted Therapy · 2022
Typeerratum
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicProtein Degradation and Inhibitors
Canadian institutionsPrincess Margaret Cancer Centre
Fundersnot available
KeywordsVenetoclaxMyeloid leukemiaCancer researchMedicineLeukemiaMyeloidMAPK/ERK pathwayImmunologyBiologySignal transductionChronic lymphocytic leukemiaGenetics

Abstract

fetched live from OpenAlex

Authors and Affiliations Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Qi Zhang, Lina Han, Yannan Jia, Vivian R. Ruvolo, Helen Ma, Connie C. Weng, Cassandra L. Ramage, Natalia Baran, Ce Shi, Tianyu Cai, Venkata L. Battula, Courtney D. DiNardo, Michael Andreeff & Marina Konopleva AbbVie Inc., North Chicago, IL, USA Bridget Riley-Gillis, Shaun E. Grosskurth, Priyanka Vijay, Sujana Ghosh, Charles Lu, Joel Leverson & Relja Popovic Institute of Hematology, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China Yannan Jia & Yingchang Mi Department of Nutritional Sciences, Department of Pediatrics, Department of Oncology, Dell Medical School, The University of Texas at Austin, Austin, TX, 78712, USA Alessia Lodi, Shannon R. Sweeney & Stefano Tiziani Department of Cell, Developmental & Cancer Biology, Division of Hematology & Medical Oncology, Knight Cancer Institute, Oregon Health & Science University, Portland, OR, USA Haijiao Zhang, Stephen Kurtz & Jeffery W. Tyner Université de Paris, Institut de la Recherche Saint-Louis (IRSL), Inserm Unit 1131, Paris, France Saravanan Ganesan & Rose Ann Padua Dana-Farber Cancer Institute, Boston, MA, USA Rongqing Pan, Jeremy A. Ryan & Anthony Letai Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Sergej N. Konoplev, Aaron Schimmer & Carlos E. Bueso-Ramos Princess Margaret Cancer Center, Toronto, ON, Canada Yulia Jitkova High Resolution Electron Microscopy Facility, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Kenneth Dunner Jr Department of Bioinformatics & Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Wencai Ma & Jing Wang Department of Hematology, The First Hospital Affiliated Harbin Medical University, Harbin, China Ce Shi Department of Lymphoma & Myeloma Research, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Richard Eric Davis Authors Qi Zhang View author publications You can also search for this author in PubMed Google Scholar Bridget Riley-Gillis View author publications You can also search for this author in PubMed Google Scholar Lina Han View author publications You can also search for this author in PubMed Google Scholar Yannan Jia View author publications You can also search for this author in PubMed Google Scholar Alessia Lodi View author publications You can also search for this author in PubMed Google Scholar Haijiao Zhang View author publications You can also search for this author in PubMed Google Scholar Saravanan Ganesan View author publications You can also search for this author in PubMed Google Scholar Rongqing Pan View author publications You can also search for this author in PubMed Google Scholar Sergej N. Konoplev View author publications You can also search for this author in PubMed Google Scholar Shannon R. Sweeney View author publications You can also search for this author in PubMed Google Scholar Jeremy A. Ryan View author publications You can also search for this author in PubMed Google Scholar Yulia Jitkova View author publications You can also search for this author in PubMed Google Scholar Kenneth Dunner Jr View author publications You can also search for this author in PubMed Google Scholar Shaun E. Grosskurth View author publications You can also search for this author in PubMed Google Scholar Priyanka Vijay View author publications You can also search for this author in PubMed Google Scholar Sujana Ghosh View author publications You can also search for this author in PubMed Google Scholar Charles Lu View author publications You can also search for this author in PubMed Google Scholar Wencai Ma View author publications You can also search for this author in PubMed Google Scholar Stephen Kurtz View author publications You can also search for this author in PubMed Google Scholar Vivian R. Ruvolo View author publications You can also search for this author in PubMed Google Scholar Helen Ma View author publications You can also search for this author in PubMed Google Scholar Connie C. Weng View author publications You can also search for this author in PubMed Google Scholar Cassandra L. Ramage View author publications You can also search for this author in PubMed Google Scholar Natalia Baran View author publications You can also search for this author in PubMed Google Scholar Ce Shi View author publications You can also search for this author in PubMed Google Scholar Tianyu Cai View author publications You can also search for this author in PubMed Google Scholar Richard Eric Davis View author publications You can also search for this author in PubMed Google Scholar Venkata L. Battula View author publications You can also search for this author in PubMed Google Scholar Yingchang Mi View author publications You can also search for this author in PubMed Google Scholar Jing Wang View author publications You can also search for this author in PubMed Google Scholar Courtney D. DiNardo View author publications You can also search for this author in PubMed Google Scholar Michael Andreeff View author publications You can also search for this author in PubMed Google Scholar Jeffery W. Tyner View author publications You can also search for this author in PubMed Google Scholar Aaron Schimmer View author publications You can also search for this author in PubMed Google Scholar Anthony Letai View author publications You can also search for this author in PubMed Google Scholar Rose Ann Padua View author publications You can also search for this author in PubMed Google Scholar Carlos E. Bueso-Ramos View author publications You can also search for this author in PubMed Google Scholar Stefano Tiziani View author publications You can also search for this author in PubMed Google Scholar Joel Leverson View author publications You can also search for this author in PubMed Google Scholar Relja Popovic View author publications You can also search for this author in PubMed Google Scholar Marina Konopleva View author publications You can also search for this author in PubMed Google Scholar Corresponding author Correspondence to Marina Konopleva .

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.016
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Other · Consensus signal: none
Teacher disagreement score0.027
Threshold uncertainty score0.089

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.016
Meta-epidemiology (narrow)0.0020.001
Meta-epidemiology (broad)0.0020.001
Bibliometrics0.0030.001
Science and technology studies0.0020.001
Scholarly communication0.0020.001
Open science0.0030.001
Research integrity0.0060.007
Insufficient payload (model declined to judge)0.0270.017

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.010
GPT teacher head0.227
Teacher spread0.218 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations12
Published2022
Admission routes1
Has abstractno

Explore more

Same venueSignal Transduction and Targeted TherapySame topicProtein Degradation and InhibitorsFrench-language works237,207