Reply: Reimplantation should be the gold standard to treat the regurgitant bicuspid aortic valve

The author reported no conflicts of interest.The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest. The author reported no conflicts of interest. The Journal policy requires editors and reviewers to disclose conflicts of interest and to decline handling or reviewing manuscripts for which they may have a conflict of interest. The editors and reviewers of this article have no conflicts of interest. In 1992, Dr John Kirklin asked me if I believed reimplantation of the aortic valve was a reproducible operation and I said yes, but it required a sound knowledge of functional anatomy of the aortic valve and better than average technical skills. Three decades later, I still feel the same. Reimplantation of the aortic valve is an extensive and complex operative procedure, and it may never be part of the surgical armamentarium of all cardiac surgeons. Jahanyar and colleagues1Jahanyar J. El Khoury G. de Kerchove L. Reimplantation should be the gold standard to treat the regurgitant bicuspid aortic valve.J Thorac Cardiovasc Surg Tech. 2022; 13: 42-43Scopus (1) Google Scholar from Brussels probably disagree with my views and believe that reimplantation of the aortic valve is the “gold standard” treatment for incompetent aortic valve regardless of the presence or absence of associated aortic root aneurysm. Their contention is based on an experience with 189 patients with incompetent bicuspid aortic valve (BAV) followed for 5.7 years (interquartile range, 2.7-8.7), with 13 patients lost to follow-up.2de Meester C. Vanovershelde J.L. Jahanyar J. Tamer S. Mastrobuoni S. Van Dyck M. et al.Long-term durability of bicuspid aortic valve repair: a comparison of 2 annuloplasty techniques.Eur J Cardiothorac Surg. 2021; 60: 286-294Crossref PubMed Scopus (12) Google Scholar Freedom from reoperation at 12 years was 91 ± 5%, and most reoperations (5 of 8) were due to mixed lesions (stenosis and insufficiency), but no information regarding late valve function is given. Gebrine El Khoury and Hans-Joachim Schäfers are probably the 2 most experienced surgeons in the world in BAV repair. Their results are exceptionally good, and more importantly they use different techniques to repair the incompetent BAV. Are their results reproducible? My personal results with reimplantation of the aortic valve in patients with Marfan syndrome have been excellent.3David T.E. David C.M. Manlhiot C. Colman J. Crean A.M. Bradley T. Outcomes of aortic valve-sparing operations in Marfan syndrome.J Am Coll Cardiol. 2015; 66: 1445-1453Crossref PubMed Scopus (83) Google Scholar The cumulative incidence of reoperation in the aortic valve was only 5%, and the cumulative incidence of moderate or severe aortic insufficiency 8% at 15 years.3David T.E. David C.M. Manlhiot C. Colman J. Crean A.M. Bradley T. Outcomes of aortic valve-sparing operations in Marfan syndrome.J Am Coll Cardiol. 2015; 66: 1445-1453Crossref PubMed Scopus (83) Google Scholar I continue to follow these patients, and the rates of reoperation or significant aortic insufficiency remain as low as reported. Coselli and colleagues4Coselli J.S. Volguina I.V. LeMaire S.A. Connolly H.M. Sundt T.M. Milewicz D.M. et al.Midterm outcomes of aortic root surgery in patients with Marfan syndrome: a prospective, multicenter, comparative study.J Thorac Cardiovasc Surg. September 4, 2021; ([Epub ahead of print])Abstract Full Text Full Text PDF Scopus (3) Google Scholar recently reported on the outcomes of 319 patients with Marfan syndrome operated on by 49 surgeons as part of a prospective, multicenter, comparative study. Aortic valve-sparing (AVS) was performed in 239 and the Bentall procedure in 77. The authors stated that “propensity score–adjusted competing risk modeling showed associations between AVS and higher cumulative incidences of major adverse valve-related events, valve-related morbidity, combined structural valve deterioration and nonstructural valve dysfunction, and aortic regurgitation.” Based on this study, AVS is a bad operation to treat patients with aortic root aneurysm associated with Marfan syndrome. In other words, my results may not be reproducible, and as the late John Kirklin told me, good operations must be reproducible operations. I don't agree with Jahanyar and colleagues1Jahanyar J. El Khoury G. de Kerchove L. Reimplantation should be the gold standard to treat the regurgitant bicuspid aortic valve.J Thorac Cardiovasc Surg Tech. 2022; 13: 42-43Scopus (1) Google Scholar that reimplantation of the aortic valve is the “gold standard” treatment for all incompetent BAV. It may be in their hands, but the rest of us should use it only in patients with well-formed cusps without fibrosis or calcification and with main commissures aligned close to 180°. Reimplantation should be the gold standard to treat the regurgitant bicuspid aortic valveJTCVS TechniquesVol. 13PreviewMokashi and associates1 have recently shared the Cleveland Clinic's intermediate-term experience with reimplantation of tricuspid aortic valves (TAV) and bicuspid aortic valves (BAV). In a propensity score–matched analysis, the authors demonstrated excellent 5-year outcomes with 100% survival in the BAV and 98% survival in the TAV group. Freedom from reoperation in the BAV and TAV cohort was 94% and 98%, respectively. Although both procedures were done with equal safety and short-term outcomes, the authors were concerned due to greater transvalvular gradients and less ventricular reverse remodeling in the BAV cohort, as well as less freedom from reoperations in the BAV cohort at 8 years (77%). Full-Text PDF Open Access

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