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Record W4223634458 · doi:10.1111/exsy.13003

Health care intelligent system: A neural network based method for early diagnosis of Alzheimer's disease using <scp>MRI</scp> images

2022· article· en· W4223634458 on OpenAlex

Why this work is in the frame

A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.

fundA Canadian funder is recorded on the work.
no affNo Canadian affiliation: this work is invisible to an affiliation-only frame.
No Canadian affiliation. An affiliation-only frame, the usual design, would never have seen this work. It is one of the works that make the case for inverting the frame.

Bibliographic record

VenueExpert Systems · 2022
Typearticle
Languageen
FieldNeuroscience
TopicBrain Tumor Detection and Classification
Canadian institutionsnot available
FundersNorman Cousins Center for PsychoneuroimmunologyDepartment of Defence, Australian GovernmentNational Institute of Biomedical Imaging and BioengineeringCanadian Institutes of Health ResearchGenentechNational Institutes of HealthH. Lundbeck A/SBioClinicaBiogenPfizerNovartis Pharmaceuticals CorporationEisai IncorporatedTakeda Pharmaceutical CompanyAbbVieNational Institute on AgingFujirebio USAlzheimer's AssociationAlzheimer's Drug Discovery FoundationMerckEli Lilly and CompanyAlzheimer's Disease Neuroimaging InitiativeGE HealthcareZayed UniversityRoche
KeywordsDementiaComputer scienceConvolutional neural networkNeuroimagingGrey matterArtificial intelligenceMagnetic resonance imagingCognitive impairmentWhite matterArtificial neural networkCognitionDiseaseDeep learningAlzheimer's diseaseAlzheimer's Disease Neuroimaging InitiativeBinary classificationMachine learningPattern recognition (psychology)MedicinePathologyPsychiatryRadiologySupport vector machine

Abstract

fetched live from OpenAlex

Abstract Alzheimer's disease (AD) is a neurodegenerative disease that causes memory loss and is considered the most common type of dementia. In many countries, AD is commonly affecting senior citizens having an aged more than 65 years. Machine learning‐based approaches have some limitations due to data pre‐processing issues. We propose a health care intelligent system based on a deep convolutional neural network (DCNN) in this research work. It classifies normal control (NC), mild cognitive impairment (MCI), and AD. The proposed model is employed on white matter (WM), and grey matter (GM) tissues with more cognitive decline features. In the experimental process, we used 375 Magnetic Resonance Image (MRI) subjects collected from Alzheimer's disease neuroimaging initiative (ADNI), including 130 NC people, 120 MCI patients, and 125 AD patients. We extract three major regions during pre‐processing, that is, WM, GM and cerebrospinal fluid (CSF). This study shows promising classification results for NC versus AD 97.94%, MCI versus AD 92.84%, and NC versus MCI 88.15% on GM images. Furthermore, our proposed model attained 95.97%, 90.82%, and 86.87% on the same three binary classes on WM tissue, respectively. When comparing existing studies in terms of accuracy and other evaluation parameters, we found that our proposed approach shows better results than those approaches based on the CNN method.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Simulation or modeling · Consensus signal: Simulation or modeling
GenreCandidate signal: Empirical · Consensus signal: none
Teacher disagreement score0.769
Threshold uncertainty score0.872

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.001
Science and technology studies0.0010.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.071
GPT teacher head0.341
Teacher spread0.269 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it