The ghrelinergic system in zebrafish gonads is suppressed during food unavailability
Bibliographic record
Abstract
Ghrelin is an appetite stimulatory peptide that regulates reproduction in vertebrates. The acylation of ghrelin by ghrelin-O-acyltransferase (Goat) is essential for most of its functions. The ghrelinergic system (ghrelin, ghrelin receptor [Ghsr] and Goat) is present in teleost fish ovary and testis. In this research, we determined the abundance of the ghrelinergic system mRNAs in different stages of follicle (oocyte) development in zebrafish ovary. The highest levels of preproghrelin mRNA were observed in the first stage of follicular development (previtellogenesis). Significantly low levels of preproghrelin mRNA were observed in stages 3II, 4 and 5 of the follicle development. Ghsr mRNA abundance remained unchanged at early stages of follicle development and decreased in stage 5 compared to other developmental stages. A significant decrease in preproghrelin and Ghsr mRNAs in the testis, and ghsr mRNA in the ovary of zebrafish deprived of food for 3 days were found. At 7 days food deprivation, preproghrelin, ghsr and goat mRNA in the ovary and preproghrelin and goat in the testis of zebrafish were significantly reduced. These results show that metabolic status modulates gonadal ghrelinergic system in zebrafish and provide support for a role for ghrelin in fish reproduction.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.001 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".