[Retracted] Discovering Common Pathophysiological Processes between COVID‐19 and Cystic Fibrosis by Differential Gene Expression Pattern Analysis
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Post-publication record
- Nature
- Retraction
- Reason
- Concerns/Issues about Data;Concerns/Issues about Results and/or Conclusions;Concerns/Issues about Referencing/Attributions;Concerns/Issues about Peer Review;Investigation by Journal/Publisher;Investigation by Third Party;Paper Mill;Computer-Aided Content or Computer-Generated Content;Unreliable Results and/or Conclusions;
- Date
- 3/20/2024 0:00
- Flagged by OpenAlex?
- Yes
Source: Retraction Watch, joined by DOI. OpenAlex records retraction as is_retracted, a boolean over a state space with at least four values, so it cannot express an expression of concern, a correction or a reinstatement — it reports them as false, which reads as “fine”.
Abstract
Coronaviruses are a family of viruses that infect mammals and birds. Coronaviruses cause infections of the respiratory system in humans, which can be minor or fatal. A comparative transcriptomic analysis has been performed to establish essential profiles of the gene expression of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) linked to cystic fibrosis (CF). Transcriptomic studies have been carried out in relation to SARS-CoV-2 since a number of people have been diagnosed with CF. The recognition of differentially expressed genes demonstrated 8 concordant genes shared between the SARS-CoV-2 and CF. Extensive gene ontology analysis and the discovery of pathway enrichment demonstrated SARS-CoV-2 response to CF. The gene ontological terms and pathway enrichment mechanisms derived from this research may affect the production of successful drugs, especially for the people with the following disorder. Identification of TF-miRNA association network reveals the interconnection between TF genes and miRNAs, which may be effective to reveal the other influenced disease that occurs for SARS-CoV-2 to CF. The enrichment of pathways reveals SARS-CoV-2-associated CF mostly engaged with the type of innate immune system, Toll-like receptor signaling pathway, pantothenate and CoA biosynthesis, allograft rejection, graft-versus-host disease, intestinal immune network for IgA production, mineral absorption, autoimmune thyroid disease, legionellosis, viral myocarditis, inflammatory bowel disease (IBD), etc. The drug compound identification demonstrates that the drug targets of IMIQUIMOD and raloxifene are the most significant with the significant hub DEGs.
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The record
- Venue
- BioMed Research International
- Topic
- Cystic Fibrosis Research Advances
- Field
- Medicine
- Canadian institutions
- University of Saskatchewan
- Funders
- Natural Sciences and Engineering Research Council of CanadaUmm Al-Qura University
- Keywords
- PathophysiologyCoronavirus disease 2019 (COVID-19)Gene expressionCystic fibrosisGeneSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)Differential diagnosisBiology2019-20 coronavirus outbreakComputational biologyPathologyMedicineBioinformaticsGeneticsDiseaseInfectious disease (medical specialty)
- Has abstract in OpenAlex
- yes