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Record W4226101207 · doi:10.30683/1929-2279.2021.10.06

The Biological Role of Cervical Cancer Suppressor 3 (CCS-3): Literature Review

2021· article· en· W4226101207 on OpenAlexvenueno aff
Luigi Cristiano

Bibliographic record

VenueJournal of cancer research updates · 2021
Typearticle
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicCancer-related gene regulation
Canadian institutionsnot available
Fundersnot available
KeywordsCervical cancerGene isoformCancerTranslation (biology)SuppressorApoptosisDownregulation and upregulationCancer researchBiologyCell biologyBioinformaticsComputational biologyBiochemistryGeneticsGeneMessenger RNA

Abstract

fetched live from OpenAlex

CCS-3 is one of the isoforms of eEF1A1, the key protein of the translation elongation step. Discovered in 2006, it has been the subject of some studies on human cervical cancer cell lines and cervical cancer samples. These studies brought to identify its probable role as a transcriptional co-repressor but other functions are currently unknown. It has also been shown that it is able to inhibit cell growth and induce apoptosis in the tumor cells that downregulate it. Further studies could highlight its functions and its possible usefulness as a tumor marker. This review aims to brief the research about CCS-3 that has been carried out so far.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame distilled prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.

metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Bench or experimental · Consensus signal: Bench or experimental
GenreCandidate signal: Review · Consensus signal: Review
Teacher disagreement score0.368
Threshold uncertainty score0.282

Codex and Gemma teacher scores by category

CategoryCodexGemma
Metaresearch0.0010.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0000.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.025
GPT teacher head0.386
Teacher spread0.361 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one teacher head, not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designBench or experimental
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2021
Admission routes1
Has abstractyes

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