Ultrasound-enhanced drug delivery to spinal cord tumors
Bibliographic record
Abstract
The blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) are major obstacles to the treatment of CNS diseases and disorders as they prevent the passage of most therapeutic agents from the blood pool to the CNS tissue. Transient, reversible opening of the BBB using ultrasound and microbubbles (MBs) has been extensively studied and has reached clinical investigations. Ultrasound and MBs can similarly modify the BSCB, although applications in the spinal cord have received less attention. We have previously demonstrated ultrasound and MB-mediated opening of the BSCB in rodents, as well as in large animals through the intact spine, using a spine-specific pulse scheme called short-burst phase keying (SBPK). In this talk, we will discuss our work evaluating treatment control approaches for controlling SBPK exposures and will present recent results from drug delivery studies in rodent models of primary and metastatic spinal cord tumors.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".