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Addition of elotuzumab to lenalidomide and dexamethasone for patients with newly diagnosed, transplantation ineligible multiple myeloma (ELOQUENT-1): an open-label, multicentre, randomised, phase 3 trial
Meletios Α. Dimopoulos, Paul G. Richardson, Nizar J. Bahlis, Sebastian Grosicki, Michèle Cavo, Meral Beksaç, Wojciech Legieć, Anna Marina Liberati, Hartmut Goldschmidt, Andrew R. Belch, Hila Magen, Alessandra Larocca, Jacob P. Laubach, Maria Teresa Petrucci, Donna Reece, Darrell White, María‐Victoria Mateos, Ivan Špıčka, Mihaela Lazaroiu, Jesús G. Berdeja, Jonathan L. Kaufman, Ying‐Ming Jou, Alex Ganetsky, Mihaela Popa McKiver, Sagar Lonial, Katja Weisel, Irwindeep Sandhu, Monika Podhorecka, Antonio Palumbo, Adi Shacham‐Abulafia, Iuliana Vaxman, Ofer Shpilberg, Britta Besemer, Maurizio Martelli, Roberto Foà, Paolo de Fabritiis, Tommaso Caravita di Toritto, Emanuil Gheorghita, Albert Oriol, Philip Rowlings, Angelucci Emanuele, Angelo Michele Carella, Massimo Offidani, Joan Bladé, Luis Felipe Casado, Heather Oakervee, Victoria Panelli, Luís Meza, Thomas Kühr, Miguel Granell, Don Benson, Rajesh Nair, Viran Holden, J. N. Reeves, Richard Eek, Patricia Walker, John Catalano, András Rosta, Ewa Lech‐Marańda, Christy Samaras, Tony Reiman, Robert Weaver, Péter Ács, Andrew Grigg, Bernard De Prijck, Martha Louzada, Leonard Minuk, Michaël Sébag, Martine Klausmann, Manfred Welslau, Andrzej Hellmann, Catalin Danaı̈la, Pamela S. Becker, William Bensinger, B. W. Porterfield, Manuel Modiano, Stephen Schultz, Robert Manges, H. Lee, James X Gray, Matthew P.F. Wright, Marie-Christine Vekemans, Aryan Hamed, Zoltán Gasztonyi, Gábor Mikala, Tamás Masszi, Barbara Gamberi, Kazimierz Kuliczkowski, Lidia Usnarska‐Zubkiewicz, Enrique Garcíá Bengoechea, María AE Gutiérrez, Jesús F. San Miguel, Christoph Driessen, Rajesh Behl, Warren Brenner, Carl Gray, Vincent Hansen, Mehdi M. Moezi, Hector V Cortes, Charles Yen, Laurent Gressot, Noemi Horvath, James M. D’Rozario, Maya Latimer, Maria-Christine Kyrtsonis, Evgeni Chubar, Moshe Mittelman, Luca Baldini, Patrizia Tosi, Angelo Vacca, W Wiktor-Jędrzejczak, Tadeusz Robak, Juan José Lahuerta, Jennifer Carney, Franklin Chen, Robert L. Hirsch, Marco Ruiz, Alvaro J. Alencar, Madan Jagasia, Samer S. Kasbari, Philip Kuriakose, Aftab Mahmood, Madhu Chaudhry, Gary Cohen, Stephen J. Noga, Sch Roa, Andrzej Jakubowiak, Cara A. Rosenbaum, Michel Delforge, Vanessa Delrieu, Chantal Doyen, Deeren Dries, Hilde Demuynck, Rik Schots, Vladimír Maisnar, Igor Wolfgang Blau, Heinz Dürk, Andrea Kerkhoff, Martin Kropff, Markus Munder, Christoph Röllig, Christof Scheid, Argiris Symeonidis, Árpád Illés, Mark Coyne, Peter O’Gorman, Patrick Hayden, Michael O’Dwyer, Dina Ben‐Yehuda, Andrei Braester, Anatoly Nemets, Gilles Lugassy, Yossi Cohen, Naomi Rahimi‐Levene, Alberto Bosi, Sara Pezzatti, Fausto Rossini, Enrico Maria Pogliani, Mieczysław Komarnicki, Gabriela Borsaru, Răzvan Stoia, Boris V. Afanasyev, María Ángeles Goñi, Ana Vallés Carboneras, Sarah Ghulam Alì, S. Eric Rubenstein, Salvador Caputto, Thomas M. Cosgriff, Suzanne Fanning, Ali Khojasteh, Andrew Liman, Albert Malcolm, Nandagopal Vrindavanam, Ravindranath Patel, Rajesh Belani, Marie Shieh, Keith Stockerl‐Goldstein, Charles M. Strnad, Robert K. Stuart, Saurabh Chhabra, Luciano da Fontoura Costa, Haresh Jhangiani, Bradley Augustson, Robin Filshie, Amanda Johnston, Mark Hertzberg, Philippe Mineur, Susan M. Fox, Rami Kotb, Vi Dao, Richard LeBlanc, Evžen Gregora, Annamaria Brioli, Lars‐Olof Mügge, Mathias Hänel, Christian Langer, Eleni Kapsali, Evangelos Briasoulis, Despoina Kyriakou, Izhar Hardan, Netanel A. Horowitz, Cangialosi Clotilde, Francesco Fabbiano, Barbara Castagnari, Fabio Ciceri, Gerardo Musuraca, Andrzej Deptała, Janusz Kłoczko, Marius Ioan Balea, Ana‐Maria Vlădăreanu, Victor Rossiev, Adrían Alegre, Cristina Encinas, Jorge Gayoso, Thomas Pabst, Neil Rabin, S. Arledge, Fernando Cabanillas, Joseph Catlett, Tarek Chidiac, David T. Clarkson, Madhav V. Dhodapkar, George F. Geils, Cyrus MA Khan, Entezam Sahovic, Mohamad Khasawneh, Rajesh Sehgal, Oscar Ballester, Moshe Levy, Joseph W. Fay, K. Huei Liem, Matthew A. Lunning, Julie M. Vose, Edward A. Faber, Donald E. Macfarlane, Raymond J. Hohl, Tariq Mahmood, Birbal Bhaskar, Martha P. Mims, Ira Oliff, Agne Paner, John Maciejewski, Arvinda Padmanabhan, Robert E. Richard, Amit Sanyal, Gary J. Schiller, Harry Staszewski, Don A. Stevens, Christopher Vaughn, Kevin Windsor
Bibliographic record
VenueThe Lancet Haematology · 2022
Typearticle
Languageen
FieldMedicine
TopicMultiple Myeloma Research and Treatments
Canadian institutionsDalhousie UniversityPrincess Margaret Cancer CentreInstitute of Cancer ResearchQueen Elizabeth II Health Sciences CentreUniversity of AlbertaUniversity of Calgary
FundersCelgeneEuropean Hematology AssociationBristol-Myers Squibb
KeywordsLenalidomideMedicineMultiple myelomaDexamethasoneInternal medicineClinical endpointTransplantationAutologous stem-cell transplantationOncologySurgeryClinical trial
Abstract
No abstract in any covered source. Its absence is recorded, not treated as a negative.
No abstract. This is not a gap in this database; OpenAlex has none either. 23.3% of the frame is in this state, and the screen finds HALF as much metaresearch here, so the absence is a measured bias rather than a missing field.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
metaresearch head score (Codex)0.001
metaresearch head score (Gemma)0.000
Version: codex-gemma-dda1882f352aValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Randomized trial · Consensus signal: Randomized trial
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.015
Threshold uncertainty score0.560
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
Opus teacher head0.062
GPT teacher head0.366
Teacher spread0.303 · how far apart the two teachers sit on this one work
Validation status
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
The models applied no category: nothing in the taxonomy fit this work.
Study designRandomized trial
Domainnot available
GenreEmpirical
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".
Quick stats
Citations47
Published2022
Admission routes1
Has abstractno