Exercise Capacity, Left Ventricular Diastolic Function and Arterial Compliance in Older Hypertensives with Osteoarthritis
Bibliographic record
Abstract
0195 Osteoarthritis and hypertension are the most prevalent medical conditions associated with aging. COX-2 selective inhibitors have been shown effective in the treatment of osteoarthritis with less GI (COX-1) related effects compared to conventional NSAIDs. Whether these differences could also impact on cardiovascular functioning and concomitant hypertension is unclear. PURPOSE: To evaluate the effect of a 16 week treatment of either a COX-1 selective inhibitor (naproxen) or a COX-2 selective inhibitor (celecoxib) on exercise capacity, left ventricular diastolic function (LVDF) and arterial compliance in older hypertensives with OA. METHODS: Fifteen older hypertensives with OA have participated in the preliminary analysis of the study cohort. Seven subjects were randomized to naproxen (NG) (500mg/d) and 8 subjects were randomized to celecoxib (CG) (200mg/d). Before, 4 weeks and 16 weeks after the randomization, measures of exercise capacity (VO2max) determined by exercise treadmill test, blood pressure, LVDF (early filling flow velocity (E), late filling flow velocity (A), E/A ratio, isovolumic relaxation time (IVRT) and deceleration time (DT)) and arterial compliance using VingMed-5 cardiac imaging system were assessed at rest. 24h ambulatory blood pressure (BP) was also recorded using a Spacelabs ABPM. RESULTS: At baseline, there were no significant differences in subject's characteristics, clinic BP, LVDF indices, arterial compliance, VO2max and 24h BP indices between the groups. At 4 week, percentages of SBP above 140mmHg and of DBP above 90mmHg in 24h BP were significantly lower in CG than those in NG (35.8±7.5 vs 81.5±12.3 %, 9.9±4.0 vs 53.4±6.5 %, p<.05, respectively) and the latter index tended to be lower in CG than in NG at 16 week. Within each group and between the groups, no changes were observed in LVDF indices, arterial compliance, VO2max and mean 24h SBP/DBP throughout the study. CONCLUSION: These preliminary data suggest that a COX-2 selective inhibitor may be preferable in terms of 24h blood pressure control to older hypertensives with osteoarthritis. Supported by Pharmacia Canada.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.002 |
| Science and technology studies | 0.000 | 0.003 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".