Bibliographic record
Abstract
Fgl2, has been implicated in the pathogenesis of viral-induced hepatitis, cytokineinduced fetal loss syndrome, allograft and xenograft rejection.This 432-amino-acid protein, a member of the fibrinogen-related protein superfamily was originally cloned from a mouse cytotoxic T lymphocyte cell line.Preliminary findings from our laboratory suggest that fgl2 exists both as a transmembrane protein and a secreted form with a truncated N-terminus.Studies demonstrate that fgl2 expressed on the membranes of murine hepatitis type-3 infected macrophages and endothelial cells exhibit prothrombinase activity.In contrast, no coagulant activity was detected from the T cell secreted form of fgl2.Since proteins belonging to the fibrinogen-related protein superfamily are known to exert multifaceted roles in the immune and inflammatory response, we postulated that secreted fgl2 exerts immunomodulatory activity.To examine this, we overexpressed fgl2 protein in a baculovirus expression system and studied secreted protein for its effect on primary immune responses.Purified fgl2 protein inhibited T lymphocyte proliferation in allogeneic, anti-CD3 antibody, and Con A-stimulated murine spleen cells in a dose-dependent fashion.This was inhibited by monoclonal antibodies against mouse fgl2.Decreased levels of IL-2 and IFNgamma and increased levels of IL-4 and IL-10 were observed in supernatants from an allogeneic mixed lymphocyte reaction to which purified fgl2 protein had been added.Furthermore, fgl2 protein prevented LPS-induced maturation of bone marrow-derived DC by decreasing the expression of the co-stimulatory molecules CD80 and CD86.These results provide the first evidence to demonstrate that fgl2 exerts anti-inflammatory properties with an inhibitory effect on T lymphocyte activation via promotion of a Th2 cytokine profile and inhibition of dendritic cell maturation.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".