Reaginic Antibody Production to Ascaris suum Allergen, ASC-1
Bibliographic record
Abstract
Wistar/Furth rats were immunized with DNP-Asc-1 in various hapten-to-carrier ratios. The kinetics and intensity of the anti-DNP and anti-carrier IgE responses were dependent on the extent of carrier substitution. Lightly substituted conjugates induced excellent primary antihapten and anticarrier IgE antibodies while heavily substituted conjugates induced an early, short-lived and low antihapten response, but not anticarrier antibodies. The pattern of IgG antibody production was not dependent on the degree of substitution in the ranges tested. A single injection of carrier in CFA induced suppression of IgE antibodies following an injection with hapten-carrier conjugate, but enhanced the IgG antibody response to the hapten. Preimmunization or supplemental immunization with carrier in Al(OH)3 suppressed the IgE anti-DNP response but did not prevent the appearance of anticarrier antibodies. The suppression of the antihapten IgE response was also demonstrated in an adoptive transfer system when donors of carrier-primed spleen cells were injected with carrier in CFA or with carrier in Al(OH)3. On the other hand, excellent collaboration between carrier-primed helper cells and hapten-primed antibody-forming cell precursors was demonstrated for both IgE and IgG antibody production when donors of either carrier-primed or of hapten-primed cells received Bordetella pertussis as adjuvant. The results are consistent with the concept that intrinsic differences between the induction patterns of the IgE and IgG antibodies exist and that various factors contribute each in a different fashion to the dissociation of these responses.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".