Bibliographic record
Abstract
The esophagus, long considered an inactive bystander in the digestive tract, is now known to be involved in monitoring food intake by various mechanisms. This active observation can lead to various disease states, one of which is esophagitis, that is, inflammation of the esophagus. Esophagitis can have various causes. One culprit appears to be the presence and activation of white blood cells called eosinophils in the esophagus. This study proposed that eosinophils release a chemical known as major basic protein (MBP) that causes esophageal inflammation. Experiments involving a living cell model of the lining of the esophagus and biopsies taken from pediatric patients confirmed this mechanism. Specifically, gene induction and gene silencing experiments confirmed that a cellular receptor in the esophagus binds to the MBP that is released from eosinophils. Further restitution and proliferation experiments suggest that certain genes, when induced by MBP stimulate growth and migration of the cells that line the esophagus.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.004 | 0.003 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.001 |
| Open science | 0.001 | 0.000 |
| Research integrity | 0.000 | 0.001 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".