Mechanism of superoxide anion-induced modulation of vascular tone
Bibliographic record
Abstract
We investigated the effects of superoxide anions (O 2 −) generated by xanthine (X) plus xanthine oxidase (XO) on isolated rabbit aorta suspended in Krebs-Ringer solution. Xanthine plus xanthine oxidase produced concentration-dependent contractions of rabbit aorta. Superoxide dismutase completely reversed the contractile response observed. Superoxide anion-induced contraction of rabbit aorta was totally abolished in preparations denuded of endothelium. The contractile effect was reduced by 56% by the cyclooxygenase inhibitor, indomethacin. The contractile effect was not affected by the angiotensin converting enzyme inhibitor, captopril. These results indicate that O 2 − produces a contraction of the isolated rabbit aorta that is endothelium-dependent and is partly mediated by an arachidonic acid metabolite.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".