PT593. CSF Beta-Amyloid and APOE E4 Related Decline in Episodic Memory over 12 months measured using the CANTAB in individuals with amnestic MCI: Results from the European-ADNI study
Bibliographic record
Abstract
Abstract Background: Accumulation of beta amyloid (Aβ) in the brain and carriage of the apolipoprotein E (APOE) ɛ4 allele have both been reported to independently and interactively linked with greater neurodegeneration, cognitive decline and incipient Alzheimer’s disease (AD). However, as most studies have observed these effects over 18-months or more, the effect of Aβ and ɛ4 on cognitive decline over 12-months remains unknown. Detecting rapid cognitive decline is critical for monitoring efficacy over shorter periods. In this study we examined the effects of Aβ and ɛ4 on rates of cognitive change assessed using the CANTAB over 12-months in aMCI patients. Methods: 145 participants with aMCI were recruited from the European-ADNI study. They were aged between 55–90, had a ≥1SD deficit in episodic memory and fulfilled a clinical diagnosis of aMCI. Participants underwent cognitive assessment using the CANTAB at baseline, 6 and 12 months and lumbar punctures for CSF measurement of Abeta42. Individuals were divided into Aβ+ (CSF-POS) (<550pg/ml)(n=55) and Aβ- (CSF-NEG)(>550pg/ml)(n=90). Results: Aβ+ aMCI individuals (relative to Aβ-) showed faster decline in paired associates learning (PAL) (p=0.02, ES=0.4) over 12 months. Aβ+ aMCI individuals who were APOE ɛ4 carriers (compared to non- carriers) had a greater decline in PAL (p<0.01, ES=0.6). No other cognitive domain including attention and executive function were affected by Aβ positivity and/or APOE ɛ4 carriage. Conclusions: Aβ+ individuals with aMCI declined at a faster rate over 12-months on episodic memory. The decline in memory in Aβ+ individuals with aMCI was exacerbated by the presence of the APOE ɛ4 allele. Other cognitive domains including psychomotor speed, attention and executive function were not affected Aβ positivity and/or APOE e4 carriage. These findings suggest a memory decline in Aβ+ individuals with aMCI can be detected as early as 12 months using the CANTAB PAL task of episodic memory.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".