Hot off the Press: A potentially new target for stroke recovery… ‘Nox’ at the door
Bibliographic record
Abstract
While many sources of ROS contribute to oxidative stress (xanthine oxidases, lipoxygenases and mitochondrial respiratory chain oxidation), Nox enzymes produce physiologically significant O 2 -• and H2O2 throughout the body (reviewed in 4 ).The Nox family consists of seven members (Nox1-5, Duox1-2).Nox5 is potentially a good target for therapies because it differs from other Nox isoforms in terms of its activation and tissue distribution.Most Nox isoforms are dependent on protein cofactors for their activity (e.g., p22phox), but Nox5 is not 5 .Furthermore, while Nox5 is structurally similar to other Noxes in that it contains conserved C-terminal NADPH and FAD binding domains and 6 transmembrane-spanning regions, its amino terminus harbours multiple EF-hands that regulate its activity in response to intracellular Ca 2+ 6 .Phosphorylation of amino acid residues alters EF-hand domain conformation to enhance Nox5 sensitivity to physiological Ca 2+ levels 7 .
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.001 | 0.001 |
| Scholarly communication | 0.003 | 0.004 |
| Open science | 0.001 | 0.001 |
| Research integrity | 0.003 | 0.005 |
| Insufficient payload (model declined to judge) | 0.043 | 0.013 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".