MétaCan
Menu
Back to cohort
Record W4231829607 · doi:10.1002/ijc.24662

Letter to the editor

2009· letter· en· W4231829607 on OpenAlexaff
Kafi N. Ealey, Michael C. Archer

Bibliographic record

VenueInternational Journal of Cancer · 2009
Typeletter
Languageen
FieldMedicine
TopicAdipokines, Inflammation, and Metabolic Diseases
Canadian institutionsUniversity of Toronto
Fundersnot available
KeywordsAdiponectinEndocrinologyInsulin resistanceInternal medicineObesityTransgeneGenetically modified mouseInsulinBiologyMedicineGeneGenetics

Abstract

fetched live from OpenAlex

We thank Drs. Chen and Huang for their interest in our paper and for their comments. We wish to emphasize that all of our mice, both transgenic and controls, were fed the high fat diet, and there were no differences in body weights between the groups. It was not our intention to study the effects of adiponectin in obesity, but rather in a background of insulin resistance. We did, indeed, see a diet-induced decrease in glucose tolerance that occurred early during carcinogenesis in all mice, irrespective of genotype. The transgenic mice, however, displayed better insulin sensitivity than their littermate controls. Under these conditions, high levels of circulating adiponectin were not protective against colon tumor development. We agree with Drs. Chen and Huang that the effect of adiponectin may be different in obese animals and this need to be investigated. Yours sincerely, Kafi N. Ealey, Michael C. Archer.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.002
metaresearch head score (Gemma)0.018
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesInsufficient payload (model declined to judge)
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: Not applicable
GenreCandidate signal: Editorial · Consensus signal: none
Teacher disagreement score0.993
Threshold uncertainty score0.023

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0020.018
Meta-epidemiology (narrow)0.0010.001
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0010.000
Science and technology studies0.0020.001
Scholarly communication0.0020.003
Open science0.0020.001
Research integrity0.0170.019
Insufficient payload (model declined to judge)0.0070.008

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.012
GPT teacher head0.310
Teacher spread0.298 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

Study designNot applicable
Domainnot available
GenreEditorial

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2009
Admission routes1
Has abstractyes

Explore more

Same venueInternational Journal of CancerSame topicAdipokines, Inflammation, and Metabolic DiseasesFrench-language works237,207