Bibliographic record
Abstract
Drugs such as penicillin and insulin have treated human disease for years, leading to both an improved quality of life, as well as an increase in overall life expectancy.Despite large amounts of biomedical data being available, the data is not being harnessed due to integration issues between datasets and heterogeneity between ontologies.Here, the use of semantic technologies in drug repurposing and drug safety is explored as it would greatly help the pharmaceutical industry answer difficult questions.Hypotheses studied include the use of mappings between model phenotypes and drug effects to identify human drug targets, and using pre-existing data as evidence to profile drug safety.Mappings done manually proved to be of better quality in comparison to automatic mappings.Evaluating drug related cardiotoxicity based on existing data was demonstrated to be successful for drug safety profiling.The results of this work demonstrate the usefulness of using pre-existing data to discover new knowledge. 3.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.008 | 0.012 |
| Meta-epidemiology (narrow) | 0.001 | 0.001 |
| Meta-epidemiology (broad) | 0.001 | 0.003 |
| Bibliometrics | 0.004 | 0.006 |
| Science and technology studies | 0.001 | 0.002 |
| Scholarly communication | 0.006 | 0.010 |
| Open science | 0.002 | 0.005 |
| Research integrity | 0.001 | 0.004 |
| Insufficient payload (model declined to judge) | 0.003 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".