Eighth International Conference on the Juvenile Hormones
Why this work is in the frame
A frame that forgets how it found something cannot be audited. These are the routes that admitted this work.
Bibliographic record
Abstract
The biosynthesis of juvenile hormone (JH) by the corpora allata (CA) can be either stimulated or inhibited by neuropeptides termed allatotropin (AT) or allatostatin (AS), respectively.To date, only one AT has been identified.It was first isolated from heads of pharate adults of Manduca sexta (Manse-AT; GFKNVEMMTARGF-NH2).The gene encoding Manse-AT has been cloned from various lepidopterans, including S. frugiperda.Here we report the identification of a second peptide with allatotropic activity from the brain of S. frugiperda by molecular techniques.A cDNA that encodes 53 amino acids included one copy of the RVRG NPISCF-OH peptide.This peptide strongly stimulated the synthesis and release of JH in vitro by the CA of female adult S. frugiperda and was code-named Spofr-AT 2. The stimulation was dose-dependent with an app.EC 50 of ca. 10 -7 M. CA that were activated with Spofr-AT 2 could be inhibited by the addition of Manse-AS to the incubation medium.Northern blotting and RT-PCR analyses revealed that the preprohormone is expressed in the brain, midgut, and ovary in a developmental-specific manner.Whole-mount in situ hybridisation confirmed the gene expression in various tissues of adult females.
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Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.001 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it