Combined Analysis of Three Genome-Wide Association Studies on vWF and FVIII Plasma Levels
Bibliographic record
Abstract
Elevated plasma levels of factor VIII (FVIII) and von Willebrand factor (vWF), two key molecules of the coagulation cascade, are well-established risk factors for venous thrombosis (VT) [1-3]. More recent evidence shows that these plasma hemostatic proteins are also risk factors for other cardiovascular diseases (CVD) [4-8]. The broader role of FVIII and vWF is further supported by studies showing that genetic factors modulating the variability of these proteins are also associated with CVD. These include single nucleotide polymorphisms (SNPs) at the BAI3 [9], LDLR [5,10], VWF [4] and ABO [11] genes, the latter being associated with other quantitative risk factors for CVD [12,13].
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".