Inflammation and Exercise-Induced Arterial Hypoxemia in the Asthmatic Female Athlete
Bibliographic record
Abstract
0859 It has been suggested that habitual exercise training may cause mechanically or chemically mediated endothelial dysfunction in the lung during heavy exercise, which may lead to exercise-induced arterial hypoxemia (EIAH). Elevated plasma P-selectin along with IL-6 have been present in acute lung injury and also after intense exercise. PURPOSE: To determine whether asthmatic female athletes (A) have higher prevalence of EIAH and higher plasma levels of soluble P-selectin and IL-6 when compared to nonasthmatic female athletes (NA). METHODS: 16 (A) (age = 26.4 ± 5.7 yrs; ht = 165.7 ± 7.6 cm; wt = 61.7 ± 10.9 kg; VO2max = 46.8 ± 8.0 mL·kg−1·min−1) and 16 (NA) (age = 26.2 ± 4.2 yrs; ht = 167.2 ± 6.8 cm; wt = 57.5 ± 6.0 kg; VO2max = 51.9 ± 8.2 mL·kg−1·min−1) were tested during the mid-follicular phase of their menstrual cycle. Subjects completed an incremental maximal treadmill test on the first day of testing and a run to exhaustion test (RTE) at 90% of VO2max on the second day of testing. P-selectin and IL-6 were measured by enzyme immunoassay before and after the treadmill run to exhaustion test. RESULTS: On Day 1 EIAH (%SaO2 ≤ 93%) was seen in 7 of the 16 A and 8 of the 16 NA. On Day 2 during the RTE, 6 of 16 A decreased %SaO2 to less than 93%, whereas 9 of the 16 NA developed EIAH. The data failed to show significance (p >0.05) in %SaO2 between groups after exercise on Day 1 or Day 2. There was a significant increase over time for both P-selectin and IL-6, but there was no difference between the asthmatic and non-asthmatic group. CONCLUSION: The prevalence of EIAH is not significantly higher in an asthmatic population when compared to nonasthmatic athletes. However, increased plasma level of P-selectin and IL-6 were seen in both groups and therefore cannot support the hypothesis that asthmatics show increased levels of inflammation due to lung damage from chronic-recurrent high stresses of breathing during exercise training.
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How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.001 | 0.000 |
| Bibliometrics | 0.000 | 0.002 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".