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Record W4233809820 · doi:10.22215/etd/2016-11286

Assessing the Acute Effects of CDP-Choline on Sensory Gating and Cognitive Deficits in Chronic Schizophrenia

2016· dissertation· en· W4233809820 on OpenAlexaff
Robert Aidelbaum

Bibliographic record

Venuenot available
Typedissertation
Languageen
FieldBiochemistry, Genetics and Molecular Biology
TopicNicotinic Acetylcholine Receptors Study
Canadian institutionsCarleton University
Fundersnot available
KeywordsSensory gatingCholineCognitionSchizophrenia (object-oriented programming)GatingPsychologyAgonistNeuroscienceMedicineInternal medicineReceptorPsychiatry

Abstract

fetched live from OpenAlex

Deficits as a Core Clinical FeatureSchizophrenia (SZ) is a chronic brain disorder affecting approximately 21 million people worldwide (WHO, 2015).It is characterized by a number of symptoms appearing heterogeneously.Primarily, SZ has come to be associated with positive symptoms and negative symptoms (Keefe & Fenton, 2007).Positive symptoms encompass disturbances of cognitive, sensory, or motor processes that are not commonly observed in healthy individuals.This would include many of the trademark symptoms associated with the disorder, namely hallucinations, delusions, and disorganized thought and speech.Negative symptoms refer to the deficit of normal behaviours.This would include such symptoms as apathy, social withdrawal, and flat affect.Recently, neurocognitive deficits have come to the forefront of SZ research and

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.000
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Observational · Consensus signal: none
GenreCandidate signal: Empirical · Consensus signal: Empirical
Teacher disagreement score0.002
Threshold uncertainty score0.004

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.000
Meta-epidemiology (narrow)0.0000.000
Meta-epidemiology (broad)0.0000.000
Bibliometrics0.0000.000
Science and technology studies0.0000.000
Scholarly communication0.0000.000
Open science0.0000.000
Research integrity0.0000.000
Insufficient payload (model declined to judge)0.0010.000

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.008
GPT teacher head0.316
Teacher spread0.307 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designObservational
Domainnot available
GenreEmpirical

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2016
Admission routes1
Has abstractyes

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