Program: Thursday, October 9, 2003
Bibliographic record
Abstract
44. CSBMCB Merck-Frosst Lecture08:00–08:40, Room 71008:00 44.1Large-scale Mapping of Genetics Networks with Ordered Arrays of Yeast MutantsCharles Boone, University of Toronto, Toronto, ON, Canada45. IUBMB/PABMB Lecture08:45–09:25, Room 71008:45 45.1Control of Alternative Pre-mRNA Splicing of RNA Pol II Elongation: Faster Is Not Always BetterAlberto Kornblihtt, Universidad de Buenos Aires, Buenos Aires, Argentina09:25 Coffee Break46. Peter Dolphin Memorial Symposium Lipoproteins and Cell InteractionsThis session was made possible through an unrestricted educational grant by the Department of Biochemistry, the Faculty of Medicine, and the Office of the Vice-President Research at Dalhousie University.Chair: Roger McLeod, Dalhousie University, Halifax, Nova Scotia, CanadaCo-Chair: Catherine Lazier, Dalhousie University, Halifax, Nova Scotia, Canada09:35–11:45, Room 514ABC09:35 46.1Amino Acid Sequences Within the β1 Domain of Human Apolipoprotein B Mediate Rapid Intracellular DegradationRoger McLoed, Dalhousie University, Halifax, Nova Scotia, Canada46.2CETP: A Key Therapeutic Target in Atherogenic DyslipidemiaJohn Chapman, Hôpital de la Pitié, Paris, France46.3Macrophage Foam Cell Formation in Atherosclerosis: Regulation by the Nuclear Hormone Receptors, PPARγ, LXR and RXRMurray Huff, University of Western Ontario, London, ON, Canada46.4The ApoE-Nitric Oxide Pathway: Anti-platelet and Anti-inflammatoryJim Owen, Royal Free & University College Medical School, London, United Kingdom47. Concurrent Session 14Small GTPases in Cell MigrationChair: Anne Ridley, Ludwig Institute of Cancer Research, London, United KingdomCo-Chair: Alan Mak, Canada09:35–11:05, Room 518ABC09:35 47.1Rho GTPases: Signaling in Cell Adhesion and MigrationAnne Ridley, Ludwig Institute of Cancer Research, London, United Kingdom47.2Rho GTPases: Signaling and Transcriptional Activation in Cell Transformation and MetastasisJuan-Carlos Lacal, Instituto de Investigaciones Biomédicas, Madrid, Spain47.3The Rho Family on the MoveLouis Lim, Institute of Molecular and Cell Biology, Singapore48. Concurrent Session 15Structure and Dynamics of Protein Folding and MisfoldingChair: Valerie Daggett, University of Washington, Seattle, WA, United StatesCo-Chair: Vettai Ananthanarayanan, McMaster University, Hamilton, ON, Canada09:35–11:05, Room 519AB09:35 48.1NMR Approaches for the Study of Protein Dynamics and FunctionOscar Millett, University of Toronto, Toronto, Ontario, Canada48.2Protein Misfolding and Human Amyloid DiseasesS.T. Ferreira, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil48.3Protein Folding/Unfolding at Atomic ResolutionValerie Daggett, University of Washington, Seattle, WA, United States49. Concurrent Session 16Rational Drug DesignChair: Francois Franceschi, Rib-X Pharmaceuticals, New Haven, Connecticut, United StatesCo-Chair: Lynne Howell, Hospital For Sick Children, Toronto, ON, Canada09:35–11:05, Room 524ABC09:35 49.1Ribosome as a Drug Target: Defining Potential Sites of Antibiotic ActionAlexander Mankin, University of Illinois, Center for Pharmaceutical Biotechnology, Chicago, IL, United States49.2Structure Based Drug Design of Ribosomal AntibioticsFrancois Franceschi, Rib-X Pharmaceuticals Inc., New Haven, Connecticut, United States49.3Old and New Drugs Against Xanthine Dehydrogenase/OxidaseEmil Pai, University of Toronto, Toronto, ON, Canada50. Concurrent Session 17Molecular MotorsChair: Christine Cremo, University of Nevada-Reno, Reno, NV, United StatesCo-Chair: David Litchfield, Canada09:35–11:05, Room 520CF09:35 50.1Regulation of Smooth and Nonmuscle Myosins IIChristine Cremo, University of Nevada-Reno, Reno, NV, United States50.2Relating Structure to Mechanism in HelicasesDale Wigley, Cancer Research UK Clase Hall Laboratories, Potters Bar, United Kingdom50.3Subunit Rotation of ATP Synthase in Membranes: A Biological Nanomachine Synthesizing Energy CurrencyAtsuko Iwamoto-Kihara, Nagahama Institute for Biosciences, Japan51. Concurrent Session 18Signaling Molecules in DevelopmentChair: Sarah Childs, University of Calgary, Faculty of Medicine, Calgary, AB, CanadaCo-Chair: Ilona Skerjanc, University of Western Ontario, London, ON, Canada09:35–11:05, Room 520BE09:35 51.1Transfer of Asymetric Signals During Left-Right PatterningHiroshi Hamada, Graduate School of Frontier Biosciences, Osaka University, Osaka, Japan51.2Guidance of Angiogenesis in ZebrafishSarah Childs, University of Calgary, Faculty of Medicine, Calgary, AB, Canada51.3From Embryo to Adult: The Kidney as a Model SystemAndy McMahon, Harvard University, Cambridge, MA, United States52. Concurrent Session 19Global Analysis of Annotation, Structure, and FunctionThis session was made possible by an unrestricted educational grant by the Institute of Genetics/CIHR.Chair: Cheryl Arrowsmith, University of Toronto, Toronto, ON, Canada09:35–11:05, Room 520AD09:35 52.1Structural ProteomicsCheryl Arrowsmith, University of Toronto, Toronto, ON, Canada52.2The Comparison of Mouse and Human Genomes by ENSEMBLEduardo Eyras, The Welcome Trust Genome Campus, Cambridge, United Kingdom52.3Global Analysis of Biochemical Activities Using Protein ChipsMichael Snyder, Yale University, New Haven, CT, United States53. Concurrent Session 20DNA RepairThis session was made possible through an unrestricted educational grant by the Institute of Genetics/CIHR.Chair: Susan Lees-Miller, University of Calgary, Calgary, AB, CanadaCo-Chair: Frances Sharom, University of Guelph, Guelph, ON, Canada11:15–12:45, Room 520BE11:15 53.1Regulation of Non-homologous End Joining by PhosphorylationSusan Lees-Miller, University of Calgary, Calgary, AB, Canada53.2Repair of Damaged DNA in VertebratesShunichi Takeda, Kyoto University, Kyoto, Japan53.3Defective DNA Damage Response and Cancer RiskKum Kum Khanna, The Queensland Institute of Medical Research, Brisbane, Australia54. Concurrent Session 21Proteins in Pathology and TherapyChair: William J. Lennarz, State University of New York at Stony Brook, Stony Brook, NY, United StatesCo-Chair: Bruce Allen, Montreal Heart Institute, Montréal, QC, Canada11:15–12:45, Room 520AD11:15 54.1Ribonucleases as Antitumor AgentsRenata Piccoli, Università di Napoli Federico II, Naples, Italy54.2Hijacking of Mismatch Repair to Cause DNA Expansion in Human DiseasesCynthia McMurray, Mayo Clinic Rochester, Rochester, MN, United States54.3The Proprotein Convertases in Health and DiseaseNabil G. Seidah, Clinical Research Institute of Montréal, Montréal, QC, Canada55. Concurrent Session 22Regulation of Signal Transduction by Lipid MediatorsChair: David Brindley, University of Alberta, Edmonton, AB, CanadaCo-Chair: Elena Posse De Chaves, University Of Alberta, Edmonton, AB, Canada11:15–12:45, Room 524ABC11:15 55.1Lipid Phosphate Phosphatase 1 (LPP1) Regulates Lysophosphatidic Acid Signaling in PlateletsAndrew Morris, University of North Carolina, Chapel Hill, NC, United States55.2Computational Approaches to Phospholipid Growth Factor Receptor Structure and FunctionGabor Tigyi, University of Tennessee Health Sciences Center, Memphis, TN, United States55.3Cell Signaling by Lipid Phosphates and Their PhosphatasesDavid Brindley, University of Alberta, Edmonton, AB, Canada56. Oral Session 11Organelle ProteomicsChair: Peter S. McPherson, Montreal Neurological Institute, Montréal, QC, Canada11:15–12:45, Room 518ABC11:15 56.1Quantitative Protein Profilining in Heart Mitochondria from Diabetic Rats Using Stable Isotope Labeling with Deuterated AcrylamideIllarion Turko, University of Texas Medical School, Houston, TX, United States11:30 56.2Comprehensive Profiling of the Surface Membrane Proteome of Cancer Cells Uncovers a Substantial Overlap with the Exosomal CompartmentDavid Misek, University of Michigan, Ann Arbor, MI, United States11:45 56.3ER-mediated Phagocytosis: Phagosomes Are Competent Organelles for Antigen Cross PresentationMathieu Houde, Université de Montréal, Montréal, QC, Canada12:00 56.4Proteomics Analysis of Brain Clathrin-Coated VesiclesFrançois Blondeau, McGill University, Montréal, QC, Canada12:15 56.5Lysosomal Membrane Proteomics: Elucidating Novel Functions of the LysosomeRick Bagshaw, The Hospital for Sick Children, Toronto, ON, Canada12:30 56.6Organelle Footprinting Using GFP-tagging of Novel ProteinsJeremy Simpson, EMBL, Heidelberg, Germany57. Oral Session 12Medical Proteomics—Genetic DiseasesChair: Charles Scriver, McGill University, Montréal, QC, Canada11:15–12:45, Room 519AB11:15 57.1A Third Human Carnitine/Organic Cation Transporter (OCTN3) as a Candidate for the 5q31 Crohn's Disease Locus (IBD5)Anne-Marie Lamhonwah, Hospital for Sick Children, Toronto, ON, Canada11:33 57.2Complex Expression Pattern of the Barth Syndrome Gene Tafazzin in Murine and Human TissuesBiao Lu, University of Manitoba, Winnipeg, MB, Canada11:51 57.3The Characterization of CFTR-associated Proteins by Mass SpectrometryWilliam Thelin, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States12:09 57.4Analysis of Differentially Displayed Proteins in HeLa Cells Expressing CFTR and Δ508 CFTRNoélie Davezac, INSERM U467, Paris, France12:27 57.5Pharmacological Enhancement of Beta-hexosaminidase A Activity in Fibroblasts from an Adult Tay-Sach PatientDon Mahuran, Hospital for Sick Children, Toronto, ON, Canada58. Oral Session 13Proteomics & BiotechnologyChair: Daniel Chelsky, Caprion Pharmaceuticals, Montréal, QC, Canada11:15–14:45, Room 520CF11:15 Expression Analysis of Proteins in Human by Stable Isotope and MA, United Surface Protein Arrays for the Molecular Proteome of of Inc., United Proteome Analysis of Human Inc., United for and Chelsky, Caprion Pharmaceuticals, Montréal, QC, Concurrent Session of University, Room from in University of Signal Transduction and of and Potential of in Human University of and in Human and S. 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Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.001 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".