Stressor re-exposure effects on behaviour and expression of pro-inflammatory cytokines in male and female mice
Bibliographic record
Abstract
The neurochemical effects of stressful events involve a range of adaptive responses to environmental challenges. However, repeated stressors may result in the development of psychopathologies such as anxiety and depression. The immune signaling molecule, pro-inflammatory cytokines, has been linked to the development of such illnesses. Interestingly, distinct differences in stressor responsiveness exist between the sexes, alongside a much higher rate of affective disorders in females. In the present experiments we examined if repeated exposure to stressors would impact male and female CD-1 mice differently with respect to behaviour as well as cytokine expression. Repeatedly stressed males demonstrated impulsive behaviour along with sensitized IL-1β expression. In follow-up experiments the role of 17β-estradiol was examined, with stressed males that were exposed to estrogen showing reduced TNF-α expression while similarly treated females had a drastic elevation in IL-6. The current results demonstrate the differences in the stressor response system between the sexes.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.001 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.001 |
| Bibliometrics | 0.001 | 0.000 |
| Science and technology studies | 0.000 | 0.001 |
| Scholarly communication | 0.001 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.001 | 0.002 |
| Insufficient payload (model declined to judge) | 0.005 | 0.001 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".