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Record W4234100587 · doi:10.1016/j.bbmt.2004.11.004

Brain tumor stem cells

2005· review· en· W4234100587 on OpenAlexaff
Peter B. Dirks

Bibliographic record

VenueBiology of Blood and Marrow Transplantation · 2005
Typereview
Languageen
FieldNeuroscience
TopicNeurogenesis and neuroplasticity mechanisms
Canadian institutionsSickKids FoundationHospital for Sick Children
Fundersnot available
KeywordsBrain tumorCancer stem cellStem cellPathologyGliomaNeural stem cellMedicinePhenotypeCancer researchCancerGlioblastomaBiologyGeneInternal medicineGenetics

Abstract

fetched live from OpenAlex

Brain tumors are typically composed of morphologically diverse cells that express a variety of neural lineage markers. Study of brain tumors by traditional histopathology has yielded only a limited amount of knowledge of the clinical behavior of the tumor. It is recognized that tumors with vastly different histology have a different prognosis, but often brain tumors that share similar morphology and phenotype can have a very different prognosis and response to treatment. Although major advances have been made in the understanding of the molecular genetic alterations of some types of brain tumors [1,2], particularly medulloblastomas and malignant gliomas, and although some of these identified alterations are now beginning to guide treatment, it is not clear whether all tumor cells are equivalent in their ability to maintain the growth of the tumor.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Review · Consensus signal: none
Teacher disagreement score0.023
Threshold uncertainty score0.078

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0020.001
Science and technology studies0.0010.001
Scholarly communication0.0020.001
Open science0.0010.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0230.020

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.050
GPT teacher head0.290
Teacher spread0.240 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreReview

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations17
Published2005
Admission routes1
Has abstractyes

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