Role of hippocampal myocyte enhancer factor 2 (MEF2) in the neuroplastic and cognitive effects of environmental stressors
Bibliographic record
Abstract
Recently, the role of transcription factor myocyte enhancer factor 2 (MEF2) has prevailed as a pro-survival agent against neuronal apoptosis, promoter of neuronal development and key player in memory consolidation.The current study examines whether three different types of stressors, namely psychologically relevant, immune and chemical stress would differentially influence MEF2 expression within the hippocampus.The study examines MEF2 associations to alterations in neurogenesis and performance in cognitive task (Y-maze).Our findings show non-significant differences of MEF2 expression within animals under psychologically relevant stress and those given immune insults.However, animals treated with environmental toxin paraquat showed declines in MEF2 levels within subgroups that scored low on the cognitive task.Moreover, we report novel findings of lowered neurogenesis within the hippocampus as a direct result of administration of environmental toxin and immune stressor.Our results add to the growing MEF2 body of work and open the door to future exploration.
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How this classification was reachedexpand
Full frame machine prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.
Distilled classifier scores by category (both heads)
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.000 | 0.000 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.000 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.001 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".