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Record W4234562374 · doi:10.1017/cbo9781139045803.002

Classification of chemical messengers

2015· book-chapter· en· W4234562374 on OpenAlexaff
Michael Wilkinson, Richard E. Brown

Bibliographic record

VenueCambridge University Press eBooks · 2015
Typebook-chapter
Languageen
FieldNeuroscience
TopicRegulation of Appetite and Obesity
Canadian institutionsDalhousie University
Fundersnot available
KeywordsNeuroendocrinologyNeuroscienceEndocrine systemReading (process)HormonePhysiologyCognitive sciencePsychologyBiologyEndocrinology

Abstract

fetched live from OpenAlex

Hormones, the brain and behavior Neuroendocrinology is the study of how the brain controls the endocrine systems that keep us alive and able to reproduce. However, an essential and critical characteristic of this neural control of the endocrine systems is that endocrine hormones in turn have profound effects on brain function through feedback systems. Research on hormones and the brain is intensive and covers many fields: from cell and molecular biology and genetics to anatomy, physiology, pharmacology, biochemistry, medicine, psychiatry and psychology. This book will examine the interactions between hormones, the brain and behavior. Thus, the primary focus will be on how the endocrine and nervous systems affect each other to produce an integrated functional neuroendocrine system that influences physiological and behavioral responses. As preliminary background reading, students are referred to any modern text on Human Physiology (see “Further reading” at the end of this chapter). When you hear the term “hormone,” for example steroid hormone , you think of the endocrine glands and how their secretions influence physiological responses in the body, but this is only part of the picture. Many of the endocrine glands (although not all of them) are influenced by the pituitary gland, the so-called “master gland,” and the pituitary is itself controlled by various hormones secreted from the hypothalamus, a part of the brain situated directly above the pituitary gland. The release of hypothalamic hormones is in turn regulated by neurotransmitters released from nerve cells (neurons) in the brain. Some neurotransmitters released within the brain also control behavior, and the secretion of neurotransmitters from specific nerve cells can be modulated by the level of specific endocrine hormones in the circulation. This is called hormone feedback. Thus, neurotransmitter release influences both hormones and behavior and, in turn, hormones regulate the release of neurotransmitters. This interaction between hormones, the brain and behavior involves a wide variety of chemical messengers which are described in this chapter.

Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.

How this classification was reachedexpand

Full frame machine prediction

Teacher imitation

Not calibrated prevalence, not ground truth. Human validation pending. The Gemma side is a direct model label for every work in the frame, read from the title-only record. The Codex side is a classifier learned from the 10,348 direct Codex labels and calibrated to design-weighted sample rates; fields without enough sample support carry no Codex call. Candidate is the union of the two sides; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels.

metaresearch head score (Codex)0.000
metaresearch head score (Gemma)0.001
Version: metacan-v3-hybrid-931329e0061cValidation status: machine_predicted_unvalidated
Candidate categoriesnone
Consensus categoriesnone
DomainCandidate signal: none · Consensus signal: none
Study designCandidate signal: Not applicable · Consensus signal: none
GenreCandidate signal: Other · Consensus signal: Other
Teacher disagreement score0.040
Threshold uncertainty score0.133

Distilled classifier scores by category (both heads)

CategoryCodexGemma
Metaresearch0.0000.001
Meta-epidemiology (narrow)0.0010.000
Meta-epidemiology (broad)0.0010.001
Bibliometrics0.0030.003
Science and technology studies0.0010.002
Scholarly communication0.0050.004
Open science0.0020.001
Research integrity0.0010.002
Insufficient payload (model declined to judge)0.0400.025

Machine scores (provisional)

The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.

Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.

Opus teacher head0.062
GPT teacher head0.237
Teacher spread0.174 · how far apart the two teachers sit on this one work
Validation statusscore_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from it

Classification

machine, unvalidated

Machine predicted; a candidate call from one source (direct Gemma or distilled Codex), not a consensus.

The models applied no category: nothing in the taxonomy fit this work.
Study designNot applicable
Domainnot available
GenreOther

How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".

Quick stats

Citations0
Published2015
Admission routes1
Has abstractyes

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