Salvage systemic therapy for advanced gastric and oesophago-gastric junction adenocarcinoma
Bibliographic record
Abstract
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows: Primary objective To assess the effects of systemic chemotherapy and biological therapy, either alone or in combination, on overall survival (OS) and progression‐free survival (PFS) in patients with advanced gastric and oesophago‐gastric junction (OGJ) adenocarcinoma, whose disease has progressed or relapsed on first line fluoropyrimidine and platinum‐containing chemotherapy. Secondary objectives To assess the effect of the aforementioned intervention on tumour response, adverse effects and quality of life; To assess the impact of patients' geographical regions (East and South‐East Asia versus regions other than East and South‐East Asia) on the survival benefit of salvage systemic therapy for advanced gastric and OGJ adenocarcinoma; and To compare the survival benefit of salvage systemic therapy for advanced gastric and OGJ adenocarcinoma in second versus third line setting.
Fetched live from OpenAlex and de-inverted. Abstracts are not stored in this database: the inverted indexes are 8.6 GB of the frame’s 9.3 GB of text, and the host has 13 GB free.
How this classification was reachedexpand
Full frame distilled prediction
Teacher imitationNot calibrated prevalence, not ground truth. Human validation pending. Learned from the 10,348 direct Codex labels and 10,348 direct Gemma labels. Candidate is the union of thresholded teacher heads; consensus is their intersection. These outputs are machine_predicted_unvalidated and are not human labels or direct frontier model labels.
Codex and Gemma teacher scores by category
| Category | Codex | Gemma |
|---|---|---|
| Metaresearch | 0.002 | 0.001 |
| Meta-epidemiology (narrow) | 0.000 | 0.000 |
| Meta-epidemiology (broad) | 0.002 | 0.000 |
| Bibliometrics | 0.000 | 0.000 |
| Science and technology studies | 0.000 | 0.000 |
| Scholarly communication | 0.000 | 0.000 |
| Open science | 0.000 | 0.000 |
| Research integrity | 0.000 | 0.000 |
| Insufficient payload (model declined to judge) | 0.000 | 0.000 |
Machine scores (provisional)
The two teacher heads of the student model, read on this work. A score orders the frame for review; it never asserts a category, and the validation status ships verbatim with every row.
Baseline scores from an immature model (maturity gate not passed, 7 training rounds). Scores rank; they never assert a category.
score_only:v0-immature-baseline · verbatim from the scoring run: score_only means the number may rank works, and no category label ships from itClassification
machine, unvalidatedMachine predicted; a candidate call from one teacher head, not a consensus.
How this classification was reached, model by model and score by score, is at the end of the page under "How this classification was reached".